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Abstract
We present a method of creating three dimensional microfluidic channel networks and freestanding microstructures using liquid phase photopolymerization techniques. The use of liquid phase microfabrication facilitates the creation of microstructured devices using low-cost materials and equipment. The ability to add multiple layers allows for complex geometries and increases the functional density of channeled devices. The multilayer technique provides a method of interconnecting layers or combining separate layers to form a truly integrated multilayered microfluidic device, as well as a means of forming multilayered freestanding structures. Because this method is based on the fundamentals of microfluidic tectonics (μFT), all components (valves, mixers, filters) compatible with μFT can be integrated into the multilayer channel networks.
References
| 1. | Kovacs, G. T., Maluf, M. I., Petersen, K. E. Bulk micromachining of silicon. Proc. of the IEEE 1998, 86, 1536–1551. Google Scholar |
| 2. | Bustillo, J. M., Howe, R. T., Muller, R. S. Surface micromachining for microelectromechanical systems. Proc. of the IEEE 1998, 86, 1552–1574. Google Scholar |
| 3. | Becker, H., Gartner, C. Polymer microfabrication methods for microfluidic analytical applications. Electrophoresis 2000, 21, 12–26. Google Scholar |
| 4. | Jackman, R. J., Floyd, T. M., Ghodssi, R., Schmidt, M., Jensen, K. Microfluidic systems with on-line UV detection fabricated in photodefinable epoxy. J. Micromech. Microeng. 2001, 11, 263–269. Google Scholar |
| 5. | Belfield, K., Schafer, K., Liu, Y., Liu, J., Ren, X., Van Stryland, E. Multiphoton-absorbing organic materials for microfabrication, emerging optical applications and non-destructive three-dimensional imaging. J. Phys. Org. Chem. 2000, 13, 837–849. Google Scholar |
| 6. | Beebe, D. J., Moore, J. S., Bauer, J. M., Yu, Q., Liu, R. H., Devadoss, C., Jo, B. H. Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature 2000, 404, 588–590. Google Scholar |
| 7. | Beebe, D. J., Moore, J. S., Yu, Q., Liu, R., Kraft, M., Jo, B., Devadoss, C. Microfluidic tectonics: A comprehensive construction platform for microfluidic systems. PNAS 2000, 97, 13488–13493. Google Scholar |
| 8. | Khoury, C., Mensing, G. A., Beebe, D. J. Ultra rapid prototyping of microfluidic systems using liquid phase photopolymerization. Lab on a Chip 2002, 2, 50–55. Google Scholar |
| 9. | Zhang, X., Jiang, X. N., Sun, C. Microstereolithography of polymeric and ceramic microstructures. Sensors and Actuators a-Physical 1999, 77, 149–156. Google Scholar |
| 10. | Sun, H. B., Tanaka, T., Takada, K., Kawata, S. Two-photon photopolymerization and diagnosis of three-dimensional microstructures containing fluorescent dyes. Appl. Phys. Lett. 2001, 79, 1411–1413. Google Scholar |
| 11. | Liu, R. H., Sharp, K. V., Olsen, M. G., Stremler, M., Santiago, J. G., Adrian, R. J., Aref, H., Beebe, D. J. Passive mixing in a threedimensional serpentine microchannel. J. of Microelectromechanical Systems 2000, 9, 190–197. Google Scholar |
| 12. | Jo, B. H., Lerberghe, L. M. V., Motsegood, K. M., Beebe, D. J. Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer. J. of Microelectromechanical Systems 2000, 9, 76–81. Google Scholar |
| 13. | Moorthy, J., Mensing, G., Kim, D., Mohanty, S., Eddington, D., Tepp, W., Johnson, E., Beebe, D. J. Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enxyme-linked immunosorbent assay system. Electrophoresis 2004, 25, 1705–1713. Google Scholar |
