Free access

Editorial

First published online October 1, 2014

Rhinosinusitis and Asthma: A Very Long Engagement

A. Licari, S. Caimmi, L. Bosa, A. Marseglia, G.L. Marseglia [email protected], and D. CaimmiView all authors and affiliations

https://doi.org/10.1177/039463201402700405

Abstract

Upper and lower airways may be considered as a unique entity, interested by coexisting inflammatory processes that share common etiopathogenic mechanisms. Previous studies have strongly demonstrated a relationship between rhinosinusitis and asthma. This has led to the introduction of the concept of “united airways”, which has also been included in the WHO document Allergic Rhinitis and its Impact on Asthma (ARIA); this concept has important consequences also on the treatment of these disorders. To better summarize the evident connection between upper and lower airway disease we decided to describe it as a multilayered construction, each level pointing out more deeply the relationship between these entities.

References

1. Marseglia GL, Merli P, Caimmi D, Licari A, Labó E, Marseglia A, Ciprandi G, La Rosa M. Nasal disease and asthma. Int J Immunopathol Pharmacol 2011; 24(4):7–12.

2. Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010; 126:466–76.

3. Ciprandi G, Caimmi D, Del Giudice M Miraglia, La Rosa M, Salpietro C, Marseglia GL. Recent developments in united airways disease. Allergy Asthma Immunol Res 2012; 4(4): 171–7.

4. Gelardi M, Marchisio P, Caimmi D, et al. Pathophysiology, favoring factors, and associated disorders in otorhinosinusology. Pediatr Allergy Immunol 2012; 23 (S):5–16.

5. From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2014. Available from: http://www.ginasthma.org/local/uploads/files/GINA_Report_2014_Jun11.pdf.

6. Fokkens WJ, Lund VJ, Mulloy J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl 2012; 23:3.

7. Shaaban R, Zureik M, Soussan D, et al. Allergic rhinitis and onset of bronchial hyperresponsiveness: A population-based study. Am J Respir Crit Care Med 2007; 176:659–66.

8. Bousquet J, Annesi-Maesano I, Carat F, Léger D, Rugina M, Pribil C, El Hasnaoui A, Chanal I. Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group. Clin Exp Allergy 2005; 35:728–32.

9. Antonicelli L, Micucci C, Voltolini S, et al. Allergic rhinitis and asthma comorbidity: ARIA classification of rhinitis does not correlate with the prevalence of asthma. Clin Exp Allergy 2007; 37:954–60.

10. Ciprandi G, Capasso M, Leonardi S, et al. Impaired FEF25-75 values may predict bronchial reversibility in allergic children with rhinitis or asthma. J Biol Regul Homeost Agents 2012; 26(S): 19–25.

11. Sedaghat AR, Phipatanakul W, Cunningham MJ. Prevalence of and associations with allergic rhinitis in children with chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol 2014; 78:343–47.

12. Meltzer EO, Blaiss MS, Derebery MJ, et al. Burden of allergic rhinitis: Results from the Pediatric Allergies in America survey. J Allergy Clin Immunol 2009; 124:S43–S70.

13. Baroody FM, Mucha SM, Detineo M, Naclerio RM. Nasal challenge with allergen leads to maxillary sinus inflammation. J Allergy Clin Immunol 2008; 121:1126–32.

14. Dixon AE. Rhinosinusitis and asthma: The missing link. Curr Opin Pulm Med 2009; 15:19–24.

15. Jarvis D, Newson R, Lotvall J, et al. Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe. Allergy 2012; 67:91–98.

16. Bresciani M, Paradis L, Des Roches A, Vernhet H, Vachier I, Godard P, Bousquet J, Chanez P. Rhinosinusitis in severe asthma. J Allergy Clin Immunol 2001; 107:73–80.

17. Eriksson J, Bjerg A, Lötvall J, Wennergren G, Rönmark E, Torén K, Lundbäck B. Rhinitis phenotypes correlate with different symptom presentation and risk factor patterns of asthma. Respir Med 2011; 105:1611–21.

18. Ragab A, Clement P, Vincken W. Objective assessment of lower airway involvement in chronic rhinosinusitis. Am J Rhinol 2004; 18:15–21.

19. Okayama M, Iijima H, Shimura S, Shimomura A, Ikeda K, Okayama H, Shirato K. Methacholine bronchial hyperresponsiveness in chronic sinusitis. Respiration 1998; 65:450–57.

20. Marseglia GL, Caimmi S, Marseglia A, et al. Occult sinusitis may be a key feature for non-controlled asthma in children. J Biol Regul Homeost Agents 2012; 26:S125–S31.

21. ten Brinke A, Grootendorst DC, Schmidt JT, De Bruïne FT, van Buchem MA, Sterk PJ, Rabe KF, Bel EH. Chronic sinusitis in severe asthma is related to sputum eosinophilia. J Allergy Clin Immunol 2002; 109:621–26.

22. Pearlman AN, Chandra RK, Chang D, Conley DB, Tripathi-Peters A, Grammer LC, Schleimer RT, Kern RC. Relationships between severity of chronic rhinosinusitis and nasal polyposis, asthma, and atopy. Am J Rhinol Allergy 2009; 23:145–48.

23. Obaseki D, Potts J, Joos G, et al. GA2LEN network of excellence. The relation of airway obstruction to asthma, chronic rhinosinusitis and age: Results from a population survey of adults. Allergy 2014; 69(9): 1205–14.

24. Lin DC, Chandra RK, Tan BK, et al. Association between severity of asthma and degree of chronic rhinosinusitis. Am J Rhinol Allergy 2011; 25(4):205–8.

25. Hallani M, Wheatley JR, Amis TC. Enforced mouth breathing decreases lung function in mild asthmatics. Respirology 2008; 13(4):553–8.

26. Soyka MB, Wawrzyniak P, Eiwegger T, Holzmann D, Treis A, Wanke K, Kast JI, Akdis CA. Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-gamma and IL–4. J Allergy Clin Immunol 2012; 130:1087–96.

27. Leonardi S, Vitaliti G, Marseglia GL, et al. Function of the airway epithelium in asthma. J Biol Regul Homeost Agents 2012; 26:S41–S48.

28. Sajjan U, Wang Q, Zhao Y, Gruenert DC, Hershenson MB. Rhinovirus disrupts the barrier function of polarized airway epithelial cells. Am J Respir Crit Care Med 2008; 178:1271–81.

29. Roelandt T, Heughebaert C, Hachem JP. Proteolytically active allergens cause barrier breakdown. J Invest Dermatol 2008; 12:1878–80.

30. Braunstahl GJ, Kleinjan A, Overbeek SE, Prins JB, Hoogsteden HC, Fokkens WJ. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med 2000; 161:2051–57.

31. Hens G, Raap U, Vanoirbeek J, et al. Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness. Am J Respir Cell Mol Biol 2011; 44:517–23.

32. Beeh KM, Beier J, Kornmann O, Meier C, Taeumer T, Buhl R. A single nasal allergen challenge increases induced sputum inflammatory markers in non-asthmatic subjects with seasonal allergic rhinitis: Correlation with plasma interleukin-5. Clin Exp All 2003; 33:475–82.

33. van Ree R, Hummelshøj L, Plantinga M, Poulsen LK, Swindle E. Allergic sensitization: Host-immune factors. Clin Transl Allergy 2014; 4(1): 12.

34. Bhimrao SK, Wilson SJ, Howarth PH. Airway inflammation in atopic patients: A comparison of the upper and lower airways. Otolaryngol Head Neck Surg 2011; 145:396–400.

35. Ponikau JU, Sherris DA, Kephart GM, Kern EB, Gaffey TA, Tarara JE, Kita H. Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: Is the histopathology similar to asthma? J Allergy Clin Immunol 2003; 112:877–82.

36. del Giudice M Miraglia, Marseglia GL, Leonardi S, Tosca MA, Marseglia A, Perrone L, Ciprandi G. Fractional exhaled nitric oxide measurements in rhinitis and asthma in children. Int J Immunopathol Pharmacol 2011; 24:29–32.

37. Ciprandi G, Tosca MA, Cirillo I, et al. Impaired FEF25-75 may predict high exhaled nitric oxide values in children with allergic rhinitis and/or asthma. J Biol Regul Homeost Agents 2012; 26(1S):S27–33.

38. Ciprandi G, Tosca MA, Capasso M. High exhaled nitric oxide levels may predict bronchial reversibility in allergic children with asthma or rhinitis. J Asthma 2013; 50(1):33–38.

39. Ragab A, Clement P, Vincken W. Correlation between the cytology of the nasal middle meatus and BAL in chronic rhinosinusitis. Rhinology 2005; 43:11–17.

40. Pastacaldi C, Lewis P, Howarth P. Staphylococci and staphylococcal superantigens in asthma and rhinitis: A systematic review and meta-analysis. Allergy 2011; 66:549–555.

41. Ponikau JU, Sherris DA, Kephart GM, Adolphson C, Kita H. The role of ubiquitous airbrone fungi in chronic rhinosinusitis. Curr Allergy Asthma Rep 2005; 5:472–76.

42. Newcomb DC, Peebles RS Jr. Th17-mediated inflammation in asthma. Curr Opin Immunol 2013; 25(6):755–60.

43. Liu Y, Zeng M, Liu Z. Th₁₇ response and its regulation in inflammatory upper airway diseases. Clin Exp 33. Allergy 2014; 22. 12378. [Epub ahead of print].

44. Ramasamy A, Curjuric I, Coin LJ, et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol 2011; 128:996–1005.

45. Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Nat Acad Sci USA 2009; 106:13445–50.

46. Mfuna-Endam L, Zhang Y, Desrosiers MY. Genetics of rhinosinusitis. Curr Allergy Asthma Rep 2011; 11:236–46.

47. Gevaert P, Calus L, Van Zele T, et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol 2013; 131:110–16.

48. Tsabouri S, Tseretopoulou X, Priftis K, Ntzani EE. Omalizumab for the treatment of inadequately controlled allergic rhinitis: A systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract 2014; 2:332–40.

49. Vashishta R, Soler ZM, Nguyen SA, Schlosser RJ. A systematic review and meta-analysis of asthma outcomes following endoscopic sinus surgery for chronic rhinosinusitis. Int Forum Allergy Rhinol 2013; 3:788–94.

50. Ehnhage A, Olsson P, Kölbeck KG, Skedinger M, Stjärne P; NAFS Study Group. One year after endoscopic sinus surgery in polyposis: Asthma, olfaction, and quality-of-life outcomes. Otolaryngol Head Neck Surg 2012; 146:834–41.

Cite article

Cite article

OR

If you have citation software installed, you can download article citation data to the citation manager of your choice

Information, rights and permissions

Information

Published In

International Journal of Immunopathology and Pharmacology

Volume 27, Issue 4

Pages: 499 - 508

Article first published online: October 1, 2014

Issue published: October 2014

Keywords

Rights and permissions

© 2014 SAGE Publications.

Request permissions for this article.

Request Permissions

History

Manuscript received: July 31, 2014

Published online: October 1, 2014

Issue published: October 2014

PubMed: 25572729

Authors

Affiliations

A. Licari

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy

View all articles by this author

S. Caimmi

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy

View all articles by this author

L. Bosa

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy

View all articles by this author

A. Marseglia

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy

View all articles by this author

G.L. Marseglia

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy

[email protected]

View all articles by this author

D. Caimmi

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy

View all articles by this author

Notes

Mailing address: Prof. Gian Luigi Marseglia, Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy, Tel.: +39 382502818 Fax: +39 382527976, e-mail: [email protected]

Metrics and citations

Metrics

This article was published in International Journal of Immunopathology and Pharmacology.

VIEW ALL JOURNAL METRICS

Total views and downloads: 497

^*Article usage tracking started in December 2016

See the impact this article is making through the number of times it’s been read, and the Altmetric Score.
Learn more about the Altmetric Scores

Web of Science: 29 view articles Opens in new tab

Crossref: 31

Respiratory comorbidities in severe asthma: focus on the pediatric age
Go to citation Crossref Google Scholar
Nasal Pulmonary Interactions
Go to citation Crossref Google Scholar
The Prevalence of Rhinosinusitis Disease among Asthma Patients in Saud...
Go to citation Crossref Google Scholar
Challenges in uncontrolled asthma in pediatrics: important considerati...
Go to citation Crossref Google Scholar
Prevalence of Laryngopharyngeal Reflux Related Symptoms in Patients Wi...
Go to citation Crossref Google Scholar
An update on the role of chronic rhinosinusitis with nasal polyps as a...
Go to citation Crossref Google Scholar
Type‐2 inflammatory mediators as targets for precision medicine in chi...
Go to citation Crossref Google Scholar
Pediatric use of omalizumab for allergic asthma
Go to citation Crossref Google Scholar
EFFECT OF SEX DIFFERENCE ON THE HISTOLOGICAL STRUCTURE OF BRONCHUS AND...
Go to citation Crossref Google Scholar
Current and emerging biologic therapies for allergic rhinitis and chro...
Go to citation Crossref Google Scholar
Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adoles...
Go to citation Crossref Google Scholar
Severe uncontrolled asthma in children: practical approach on diagnosi...
Go to citation Crossref Google Scholar
Measuring inflammation in paediatric severe asthma: biomarkers in clin...
Go to citation Crossref Google Scholar
Severe asthma in children: Current goals and unmet needs
Go to citation Crossref Google Scholar
The Link between Asthma and Bronchiectasis: State of the Art
Go to citation Crossref Google Scholar
Towards Precision Medicine in Pediatric Severe Asthma: An Update on Cu...
Go to citation Crossref Google Scholar
Novel Biologics for the Treatment of Pediatric Severe Asthma
Go to citation Crossref Google Scholar
Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusi...
Go to citation Crossref Google Scholar
Personalized therapies for the treatment of allergic rhinitis
Go to citation Crossref Google Scholar
Targeted Therapy for Severe Asthma in Children and Adolescents: Curren...
Go to citation Crossref Google Scholar
Asthma and Chronic Rhinosinusitis: Diagnosis and Medical Management
Go to citation Crossref Google Scholar
Relationship between Chronic Rhinosinusitis and Blood Pressure
Go to citation Crossref Google Scholar
The overlap between bronchiectasis and chronic airway diseases: state ...
Go to citation Crossref Google Scholar
Rhinosinutis and Asthma in Children
Go to citation Crossref Google Scholar
Leitlinie „Rhinosinusitis“ – Langfassung
Go to citation Crossref Google Scholar
Upper airway involvement in bronchiectasis is marked by early onset an...
Go to citation Crossref Google Scholar
Fungal Microbiota in Chronic Airway Inflammatory Disease and Emerging ...
Go to citation Crossref Google Scholar
The role of upper airway pathology as a co-morbidity in severe asthma
Go to citation Crossref Google Scholar
The Nose and the Lung: United Airway Disease?
Go to citation Crossref Google Scholar
Occurrence and impact of sinusitis in patients with asthma and/or alle...
Go to citation Crossref Google Scholar
Paranasal sinus opacification at MRI in lower airway disease (the HUNT...
Go to citation Crossref Google Scholar

Figures and tables

Figures & Media

Tables

View Options

View options

PDF/ePub

Get access

If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below:

Sage Journals profile

OR

Institution

Society

Alternatively, view purchase options below:

Purchase access

Purchase 24 hour online access to view and download content.

Read with DeepDyve