Skip to main content
Intended for healthcare professionals
Restricted access
Research article
First published online September 23, 2011

Prevalence and Incidence Rates of Dementia and Cognitive Impairment No Dementia in the Mexican Population: Data From the Mexican Health and Aging Study

Abstract

Objective: To estimate the prevalence and incidence of dementia and cognitive impairment without dementia (CIND) in the Mexican population. Method: The MHAS study is a prospective panel study of health and aging in Mexico with 7,000 elders that represent eight million participants nationally. Using measurements of cognition and activities of daily living of dementia cases and CIND were identified at baseline and follow-up. Overall incidence rates and specific rates for sex, age, and education were calculated. Results: Prevalence was 6.1% and 28.7% for dementia and CIND, respectively. Incidence rates were 27.3 per 1,000 person-years for dementia and 223 per 1,000 persons-year for CIND. Rates of dementia and CIND increased with advancing age and decreased with higher educational level; sex had a differential effect depending on the age strata. Hypertension, diabetes, and depression were risk factors for dementia but not for CIND. Discussion: These data provide estimates of prevalence and incidence of dementia and cognitive impairment in the Mexican population for projection of future burden.

Get full access to this article

View all access and purchase options for this article.

References

Avila-Funes J. A., Amieva H., Barberger-Gateau P., Le Goff M., Raoux N., Ritchie K., . . . Dartigues J. (2009). Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. Journal of the American Geriatric Society, 57, 453-461.
Busse A., Bischkopf J., Riedel-Heller S. G., Angermeyer M. C. (2003). Mild cognitive impairment: Prevalence and incidence according to different diagnostic criteria. Results of the Leipzig Longitudinal Study of the Aged (LEILA75+). The British Journal of Psychiatry, 182, 449-454.
Christensen H., Korten A. E., Jorm A. F., Henderson A. S., Jaco P. A., Rodgers R. (1997). Education and decline in cognitive performance: Compensatory but not protective international. Journal of Geriatric Psychiatry, 12, 323-330.
Di Carlo A., Baldereschi M., Amaducci L., Lepore V., Bracco L., Maggi S., . . . ILSA Working Group. (2002) Incidence of dementia, Alzheimer’s disease, and vascular dementia in Italy. The ILSA Study. Journal of the American Geriatric Society, 50, 41-48.
Evans D. A., Hebert L. E., Beckett L. A., Scherr P. A., Albert M. S., Chown M. J., . . . Taylor J. O.(1997). Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons. Archives of Neurology, 54, 1399-1405.
Glosser G., Wolfe N., Albert M. L., Lavine L., Steele J. C., Calne D. B., Schoenberg B. S. (1993) Cross-cultural cognitive examination: Validation of a dementia screening instrument for neuroepidemiological research. Journal of the American Geriatric Society, 41, 931-939
Graciani A., Banegas J. R., Guallar-Castillón P., Domínguez-Rojas V., Rodríguez-Artalejo F. (2006). Cognitive assessment of the non-demented elderly community dwellers in Spain. Dementia Geriatric Cognitive Disorders, 21, 104-112.
Gutierrez-Robledo L. M. (2006). Aging in developing countries. In Pathy J., Sinclair A. J., Morley J. E. (Eds.), Principles of geriatric medicine (pp.1965-1976). Chichester, UK: John Wiley.
Haan M. N., Mungas D. M., González H. M., Jagust W. J. (2003). Prevalence of dementia in older Mexican Americans: The influence of type 2 diabetes, stroke and genetic factors. Journal of the American Geriatric Society, 51, 169-177.
Herrera E., Caramelli P., Silveira A. S., Mathias S. C., Nitrini R. (1997) Population epidemiology survey of dementia in Catanduva, Brazil. Preliminary results. Journal of Neurological Sciences, 150, 155-156.
INEGI (2000). XII Censo General de Población y Vivienda. Instituto Nacional de Estadistica, Geografia e Informatica: Mexico.
Jones D. J., Song X., Rockwood K. (2004). Operationalizing a Frailty Index from a Standardized Comprehensive Geriatric Assessment. Journal of the American Geriatric Society, 52, 1929-1933.
Jorm A. F. (1994). A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): Development and cross-validation. Psychological Medicine, 24, 145-153.
Jorm A. F. (2000). Does old age reduce the risk of anxiety and depression? A review of epidemiological studies across the adult life span. Psychological Medicine, 30, 11-22.
Jorm A. F. (2004). The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): A review. International Psychogeriatrics, 16, 1-19.
Katzman R. (1993). Education and the prevalence of dementia and Alzheimer’s disease. Neurology, 43, 13-20.
Kemper S., McDowd J. M. (2008). Dimensions of cognitive aging. Executive function and verbal fluency. In Hofer S. M., Alwin D. F. (Eds.), Handbook of cognitive aging. Interdisciplinary perspectives. California, CA: SAGE.
Ketzoian C., Romero S., Dieguez E., Cairolo G., Rega Y., Caseres R., Chouza C. (1997). Prevalence of demential síndromes in a population of Uruguay. Study of “Villa del Cerro.” Journal of Neurological Sciences, 150, 155
Kivipelto M., Helkala E. L., Laakso M. P., Ha¨nninen T., Hallikainen M., Alhainen K., . . . Soininen H. (2002). Apolipoprotein E _4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Annals Internal Medicine, 137, 149-155.
Kloppenborg R. P., van den Berg E., Kappelle L. J., Biessels G. J. (2008). Diabetes and other vascular risk factors for dementia: Which factor matters most? A systematic review. European Journal of Pharmacology, 585, 97-108.
Knopman D. S., Boeve B. F., Petersen R. (2003). Essentials of the proper diagnoses of mild cognitive impairment, dementia and major subtypes of dementia. Mayo Clinic Proceedings, 78, 1290-1308.
Larrieu S., Letenneur L., Orgogozo J. M., Fabrigoule C., Amieva H., Le Carret N., . . . Dartigues J. F. (2002). Incidence and outcome of mild cognitive impairment in a population-based prospective cohort. Neurology, 26, 1594-1599.
Llibre Rodriguez J., Ferri C., Acosta D., Guerra M., Huang, Jacob Y., . . . Prince M. (2008). Prevalence of dementia in Latin America, India, and China: A population-based cross-sectional survey (for the 10/66 Dementia Research Group). Lancet; 372, 464-474.
Lopez O. L., Kuller L. H., Becker J. T., Dulberg C., Sweet R. A., Gach H. M., Dekosky S. T. (2007) Incidence of dementia in mild cognitive impairment in the Cardiovascular Health Study Cognition Study. Archives of Neurology, 64, 416-420
Manschot S. M., Biessels G. J., de Valk H., Algra A., Rutten G. E., Van der Grond J., . . . Utrecht Diabetic Encephalopathy Study Group. (2007). Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia, 50, 2388-2397.
Mejía S., Giraldo M., Pineda D., Ardila A., Lopera F. (2003). Non-genetic factors as modifiers of the age of onset of familial Alzheimer’s disease. International Psychogeriatrics, 15, 337-349.
Miech R. A., Breitner J. C. S., Zandi P. P., Khachaturian A. S., Anthony J. C., Mayer L. (2002). Incidence of AD may decline in the early 90s for men, later for women The Cache County Study. Neurology, 58, 209-218.
Navarrete H., Rodriguez-Leyva I. (2003). La demencia. Subdiagnosticada oignorada? Revista Mexicana de Neurociencias, 4, 11-12.
Nitrini R. (1995). Evaluation of 100 patients with dementia in Sao Paulo Brazil: Correlation with socioeconomic status and education. Alzheimer Disease and Associated Disorders, 9,146-151.
Ott A., Breteler M., van Harskamp F., Stijnen T., Hofman A. (1998). Incidence and risk of dementia. The Rotterdam Study. American Journal of Epidemiology, 147, 574-580.
Petersen R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183-194.
Plassman B. L., Langa K. M., Fisher G. G., Heeringa S. G., Weir D. R., Ofstedal M. B., . . . Wallace R. L. (2008). Prevalence of cognitive impairment without dementia in the United States. Annals of Internal Medicine, 148, 427-434.
Prince M. (2009). The 10/66 Dementia Research Group. 10 years on. Indian Journal of Psychiatry, 51, 8-15.
Quiroga P., Albala C., Klassen G. (2004). Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile. [Validation of a screening test for age associated cognitive impairment, in Chile]. Revista Médica de Chile, 132, 467-478.
Ravaglia G., Forti P., Maioli F., Martelli M., Servadei L., Brunetti N., . . . Mariani E. (2005). Incidence and etiology of dementia in a large elderly Italian population. Neurology, 64, 1525-1530.
Rockwood K., Fox R. A., Stolee P., Robertson D., Beattie B. L. (1994). Frailty in elderly people: An evolving concept. Canadian Medical Association Journal, 150, 489-495.
Scarmeas N., Albert S. M., Manly J. J., Stern Y. (2006). Education and rates of cognitive decline in incident Alzheimer’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 77, 308-316.
Skoog I., Lernfelt B., Landahl S., Palmertz B., Andreasson L. A., Nilsson L., . . . Svanborg A. (1996). 15-year longitudinal study of blood pressure and dementia. Lancet, 347, 1141-1145.
Trejo-Gutierrez J. F. (2004). Epidemiologia del sindrome metabolico y diabetes mellitus tipo2: El diluvio que viene? Archivos de Cardilogia de Mexico, 74, 267-270.
Tuokko H., Frerichs R., Graham J., Rockwood K., Kristjansson B., Fisk J., . . . McDowell I. (2003). Five-year follow-up of cognitive impairment with no dementia. Archives of Neurology, 60, 577-582.
Unverzagt F. W., Gao S., Baiyewu O., Ogunniyi A. O., Gureje O., Perkins A., . . . Hendrie H. C. (2001). Prevalence of cognitive impairment: Data from the Indianapolis Study of Health and Aging. Neurology, 13, 1655-1662.
Wolfe N., Imai Y., Otani C., Nagatani H., Hasegawa K., Sugimoto K., . . . Albert M. L. (1992) Criterion validity of the cross-cultural cognitive examination in Japan. Journal of Gerontology, 47, 289-291.
Wong R., Pelaez M., Palloni A., Markides K. (2006). Survey Data for the Study of Aging in Latin America and the Caribbean: Selected Studies. Journal of Aging and Health, 18, 157-179.
Zanetti M., Ballabio C., Abbate C., Cutaia C., Vergani C., Bergamaschini L. (2006). Mild cognitive impairment subtypes and vascular dementia in community-dwelling elderly people: A 3-year follow-up study. Journal of the American Geriatric Society, 54(4), 580-586.

Cite article

Cite article

Cite article

OR

Download to reference manager

If you have citation software installed, you can download article citation data to the citation manager of your choice

Share options

Share

Share this article

Share with email
EMAIL ARTICLE LINK

Share access to this article

Sharing links are not relevant where the article is open access and not available if you do not have a subscription.

For more information view the Sage Journals article sharing page.

Information, rights and permissions

Information

Published In

Article first published online: September 23, 2011
Issue published: October 2011

Keywords

  1. dementia
  2. cognitive impairment no dementia
  3. hypertension
  4. diabetes
  5. depression
  6. Mexican population

Rights and permissions

© SAGE Publications 2011.
Request permissions for this article.

History

Published online: September 23, 2011
Issue published: October 2011
PubMed: 21948770

Authors

Affiliations

Silvia Mejia-Arango, PhD
El Colegio de la Frontera Norte, Mexico
Luis Miguel Gutierrez, PhD
Instituto de Geriatria, Mexico

Notes

Silvia Mejia-Arango, El Colegio de la Frontera Norte, Mexico Email: [email protected]

Metrics and citations

Metrics

Journals metrics

This article was published in Journal of Aging and Health.

VIEW ALL JOURNAL METRICS

Article usage*

Total views and downloads: 661

*Article usage tracking started in December 2016

Articles citing this one

Web of Science: 83 view articles Opens in new tab

Crossref: 79

  1. Disability-Adjusted Life Expectancy and Cognitive Function among Commu...
    Go to citation Crossref Google Scholar
  2. Gender, Personality, and Cognitive Resilience Against Early-Life Disad...
    Go to citation Crossref Google Scholar
  3. Prevalence of Dementia and Cognitive Impairment No Dementia in a Large...
    Go to citation Crossref Google Scholar
  4. Follow-up of participants with subjective cognitive decline from Treme...
    Go to citation Crossref Google Scholar
  5. Evaluation of 3D apparel design spatial visualization training for cog...
    Go to citation Crossref Google Scholar
  6. Diabetes, disability, and dementia risk: Results from the Hispanic Est...
    Go to citation Crossref Google ScholarPub Med
  7. Prevalence of dementia in Latin America and Caribbean countries: Syste...
    Go to citation Crossref Google Scholar
  8. Working in old age in Mexico: implications for cognitive functioning
    Go to citation Crossref Google Scholar
  9. Healthy Ageing in Low and Middle-Income Countries; A Systematic Scopin...
    Go to citation Crossref Google Scholar
  10. Association Between Social Participation and Cognitive Function in Com...
    Go to citation Crossref Google ScholarPub Med
  11. Prevalence of Dementia and Main Subtypes in Mexico: The Study on Aging...
    Go to citation Crossref Google Scholar
  12. Social, behavioural, and functional characteristics of community‐dwell...
    Go to citation Crossref Google Scholar
  13. Living Arrangements and Dementia Among the Oldest Old: A Comparison of...
    Go to citation Crossref Google Scholar
  14. Incidence of dementia in a Brazilian population: The Tremembé Epidemio...
    Go to citation Crossref Google Scholar
  15. Midlife Vascular Factors and Prevalence of Mild Cognitive Impairment i...
    Go to citation Crossref Google Scholar
  16. Psychometric properties of the ASEBA older adult self report in a Mexi...
    Go to citation Crossref Google Scholar
  17. Effects of diabetes and obesity on cognitive impairment and mortality ...
    Go to citation Crossref Google Scholar
  18. Prevalence, Incidence, and Progression of Cognitive Impairment, No Dem...
    Go to citation Crossref Google Scholar
  19. Solid cooking fuel use and cognitive decline among older Mexican adult...
    Go to citation Crossref Google Scholar
  20. Adult child socio-economic status disadvantage and cognitive decline a...
    Go to citation Crossref Google Scholar
  21. Dual Trajectories of Dementia and Social Support in the Mexican-Origin...
    Go to citation Crossref Google Scholar
  22. The Effect of Diabetes on the Cognitive Trajectory of Older Adults in ...
    Go to citation Crossref Google Scholar
  23. Fertility History and Cognitive Function in Late Life: The Case of Mex...
    Go to citation Crossref Google Scholar
  24. Socioeconomic Disparities and Gender Inequalities in Dementia: a Commu...
    Go to citation Crossref Google Scholar
  25. Diabetes multimorbidity combinations and disability in the Mexican Hea...
    Go to citation Crossref Google Scholar
  26. Prevalence and Risk of Mild Cognitive Impairment in Low and Middle-Inc...
    Go to citation Crossref Google Scholar
  27. Lower Levels of Education Are Associated with Cognitive Impairment in ...
    Go to citation Crossref Google Scholar
  28. Global Cognitive Impairment Prevalence and Incidence in Community Dwel...
    Go to citation Crossref Google Scholar
  29. The Mexican Cognitive Aging Ancillary Study (Mex-Cog): Study Design an...
    Go to citation Crossref Google Scholar
  30. Factors associated with functional loss among community-dwelling Mexic...
    Go to citation Crossref Google Scholar
  31. Short-Term Impact of Income on Cognitive Function: Evidence From a Sam...
    Go to citation Crossref Google ScholarPub Med
  32. Cerebrovascular Correlates of Dementia in Community-Dwelling Older Adu...
    Go to citation Crossref Google Scholar
  33. Late life depressive symptoms and cognitive function among older Mexic...
    Go to citation Crossref Google Scholar
  34. Carotid Intima-media Thickness, Cognitive Performance and Cognitive De...
    Go to citation Crossref Google Scholar
  35. Health and social correlates of dementia in oldest‐old Mexican‐origin ...
    Go to citation Crossref Google Scholar
  36. Behavioral and Psychosocial Treatments of Dementia in Mexico
    Go to citation Crossref Google Scholar
  37. Meta-Analysis of Dementia Rates in Central America, South America, and...
    Go to citation Crossref Google Scholar
  38. Cognitive Decline Among the Elderly: A Comparative Analysis of Mexican...
    Go to citation Crossref Google Scholar
  39. Factors associated with healthy aging in septuagenarian and nonagenari...
    Go to citation Crossref Google Scholar
  40. Cognitive decline is not influenced by the marital status or living ar...
    Go to citation Crossref Google Scholar
  41. Expansion of disability across successive Mexican birth cohorts: a lon...
    Go to citation Crossref Google Scholar
  42. Dementia Around the World and the Latin America and Mexican Scenarios
    Go to citation Crossref Google Scholar
  43. Association of depressive symptoms and subjective memory complaints wi...
    Go to citation Crossref Google Scholar
  44. Clinical and neuroimaging risk factors for cognitive decline in commun...
    Go to citation Crossref Google Scholar
  45. Changes in Plasma Amyloid and Tau in a Longitudinal Study of Normal Ag...
    Go to citation Crossref Google Scholar
  46. Chronic respiratory disease and cognitive impairment in older Mexican ...
    Go to citation Crossref Google Scholar
  47. Cardiovascular health and cognitive function among Mexican older adult...
    Go to citation Crossref Google Scholar
  48. Cognition and Context: Rural–Urban Differences in Cognitive Aging Amon...
    Go to citation Crossref Google ScholarPub Med
  49. Neuropsychiatric symptoms as risk factors of dementia in a Mexican pop...
    Go to citation Crossref Google Scholar
  50. Incidence of dementia in elderly Latin Americans: Results of the Marac...
    Go to citation Crossref Google Scholar
  51. The effect of adult children living in the United States on the likeli...
    Go to citation Crossref Google Scholar
  52. Neuroepidemiology in Latin America
    Go to citation Crossref Google Scholar
  53. Dementia
    Go to citation Crossref Google Scholar
  54. Vitamin D deficiency in older adults and its associated factors: a cro...
    Go to citation Crossref Google Scholar
  55. Association of Healthy Habits Beliefs and Mortality in Older Adults: A...
    Go to citation Crossref Google ScholarPub Med
  56. Arthritis and Risk of Cognitive and Functional Impairment in Older Mex...
    Go to citation Crossref Google ScholarPub Med
  57. Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: Is Aβ a C...
    Go to citation Crossref Google Scholar
  58. Frequency and Correlates of Behavioral and Psychological Symptoms in a...
    Go to citation Crossref Google Scholar
  59. The association between social support and cognitive function in Mexic...
    Go to citation Crossref Google Scholar
  60. Evaluation of cognitive impairment in elderly population with hyperten...
    Go to citation Crossref Google Scholar
  61. Factors associated with cognitive function in older adults in Mexico
    Go to citation Crossref Google Scholar
  62. The Effect of Undiagnosed Diabetes on the Association Between Self-Rep...
    Go to citation Crossref Google ScholarPub Med
  63. Cancer and frailty in older adults: a nested case-control study of the...
    Go to citation Crossref Google Scholar
  64. Prevalence of Cognitive Impairment Without Dementia and Dementia in Tr...
    Go to citation Crossref Google Scholar
  65. Calf circumference predicts mobility disability: A secondary analysis ...
    Go to citation Crossref Google Scholar
  66. A Late Life Risk Index for Severe Cognitive Impairment in Mexico
    Go to citation Crossref Google Scholar
  67. Evaluation of inflammation-related genes polymorphisms in Mexican with...
    Go to citation Crossref Google Scholar
  68. Life Expectancy with and without Cognitive Impairment in Seven Latin A...
    Go to citation Crossref Google Scholar
  69. Target risk factors for dementia prevention: a systematic review and D...
    Go to citation Crossref Google Scholar
  70. Present State of Elder Care in Mexico
    Go to citation Crossref Google Scholar
  71. Epidemiologic studies of modifiable factors associated with cognition ...
    Go to citation Crossref Google Scholar
  72. MINI-COGNITIVE TESTING IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATI...
    Go to citation Crossref Google Scholar
  73. Prevalence of Dementia, Emotional State and Physical Performance among...
    Go to citation Crossref Google Scholar
  74. Kynurenines and other novel therapeutic strategies in the treatment of...
    Go to citation Crossref Google ScholarPub Med
  75. A Review of Longitudinal Datasets on Ageing
    Go to citation Crossref Google Scholar
  76. The State of Elder Care in Mexico
    Go to citation Crossref Google Scholar
  77. Dementia incidence and mortality in middle-income countries, and assoc...
    Go to citation Crossref Google Scholar
  78. Prevalence of Mild Cognitive Impairment and Its Subtypes in the Mexica...
    Go to citation Crossref Google Scholar
  79. Prevalence of cognitive impairment in individuals aged over 65 in an u...
    Go to citation Crossref Google Scholar

Figures and tables

Figures & Media

Tables

View Options

Get access

Access options

If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below:


Alternatively, view purchase options below:

Purchase 24 hour online access to view and download content.

Access journal content via a DeepDyve subscription or find out more about this option.

View options

PDF/ePub

View PDF/ePub

Full Text

View Full Text