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Abstract
Low socioeconomic status (SES) during childhood confers risk for adverse health in adulthood. Accumulating evidence suggests that this may be due, in part, to the association between lower childhood SES and higher levels of pro-inflammatory cytokines. Drawing from literature showing that low childhood SES predicts exaggerated physiological reactivity to stressors and that lower SES is associated with a more communal, socially attuned orientation, we hypothesized that inflammatory reactivity would be more greatly affected by cues of social support among individuals whose childhood SES was low than among those whose childhood SES was high. In two studies, we found that individuals with lower subjective childhood SES exhibited greater reductions in pro-inflammatory cytokine reactivity to a stressor in the presence of a supportive figure (relative to conditions with an unsupportive or neutral figure). These effects were independent of current SES. This work helps illuminate SES-based differences in inflammatory reactivity to stressors, particularly among individuals whose childhood SES was low.
References
|
Adler, N. E., Boyce, T., Chesney, M. A., Cohen, S., Folkman, S., Kahn, R. L., Syme, S. L. (1994). Socioeconomic status and health: The challenge of the gradient. American Psychologist, 49, 15–24. Google Scholar | Crossref | Medline | ISI | |
|
Adler, N. E., Newman, K. (2002). Socioeconomic disparities in health: Pathways and policies. Health Affairs, 21, 60–76. Google Scholar | Crossref | Medline | ISI | |
|
Adler, N. E., Ostrove, J. M. (1999). Socioeconomic status and health: What we know and what we don’t. Annals of the New York Academy of Sciences, 896, 3–15. Google Scholar | Crossref | Medline | ISI | |
|
Aron, A., Melinat, E., Aron, E. N., Vaollone, R., Bator, R. (1997). The experimental generation of interpersonal closeness: A procedure and some preliminary findings. Personality and Social Psychology Bulletin, 23, 363–377. Google Scholar | SAGE Journals | ISI | |
|
Carroll, J. E., Cohen, S., Marsland, A. L. (2011). Early childhood socioeconomic status is associated with circulating interleukin-6 among mid-life adults. Brain, Behavior, and Immunity, 25, 1468–1474. Google Scholar | Crossref | Medline | ISI | |
|
Chen, E. (2007). Impact of socioeconomic status on physiological health in adolescents: An experimental manipulation of psychosocial factors. Psychosomatic Medicine, 69, 348–355. Google Scholar | Crossref | Medline | ISI | |
|
Chiang, J. J., Eisenberger, N. I., Seeman, T. E., Taylor, S. E. (2012). Negative and competitive social interactions are related to heightened proinflammatory cytokine activity. Proceedings of the National Academy of Sciences, USA, 109, 1878–1882. Google Scholar | Crossref | Medline | ISI | |
|
Clark, A. M., DesMeules, M., Luo, W., Duncan, A. S., Wielgosz, A. (2009). Socioeconomic status and cardiovascular disease: Risk and implications for care. Nature Reviews Cardiology, 6, 712–722. Google Scholar | Crossref | Medline | ISI | |
|
Cohen, S., Alper, C. M., Doyle, W. J., Adler, N., Treanor, J. J., Turner, R. B. (2008). Objective and subjective socioeconomic status and susceptibility to the common cold. Health Psychology, 27, 268–274. Google Scholar | Crossref | Medline | ISI | |
|
Derry, H. M., Fagundes, C. P., Andridge, R., Glaser, R., Malarkey, W. B., Kiecolt-Glaser, J. K. (2013). Lower subjective social status exaggerates interleukin-6 responses to a laboratory stressor. Psychoneuroendocrinology, 38, 2676–2685. Google Scholar | Crossref | Medline | ISI | |
|
Dickerson, S. S., Gable, S. L., Irwin, M. R., Aziz, N., Kemeny, M. E. (2009). Social-evaluative threat and proinflammatory cytokine regulation: An experimental laboratory investigation. Psychological Science, 20, 1237–1244. doi:10.1111/j.1467-9280.2009.02437.x Google Scholar | SAGE Journals | ISI | |
|
Ellis, B. J., Boyce, T. W. (2005). Biological sensitivity to context. Current Directions in Psychological Science, 17, 185–187. Google Scholar | |
|
Galobardes, B., Lynch, J. W., Smith, G. D. (2008). Is the association between childhood cause-specific mortality and childhood socioeconomic circumstances established? Update of systematic review. Journal of Epidemiology & Community Health, 62, 387–390. Google Scholar | Crossref | Medline | ISI | |
|
Gianaros, P. J., Horenstein, J. A., Hariri, A. R., Sheu, L. K., Manuck, S. B., Matthews, K. A., Cohen, S. (2008). Potential neural embedding of parental social standing. Social Cognitive and Affective Neuroscience, 3, 91–96. Google Scholar | Crossref | Medline | ISI | |
|
Gouin, J. P., Hantsoo, L., Kiecolt-Glaser, J. K. (2008). Immune dysregulation and chronic stress among older adults: A review. Neuroimmunomodulation, 15, 251–259. Google Scholar | Crossref | Medline | ISI | |
|
Hertzman, C. (1999). The biological embedding of early experience and its effects on health in adulthood. Annals of the New York Academy of Sciences, 896, 85–95. Google Scholar | Crossref | Medline | ISI | |
|
John-Henderson, N. A., Rheinschmidt, M. L., Mendoza-Denton, R. (2014). Cytokine responses and math performance: The role of stereotype threat and anxiety reappraisals. Journal of Experimental Social Psychology, 56, 203–206. Google Scholar | Crossref | ISI | |
|
John-Henderson, N. A., Rheinschmidt, M. L., Mendoza-Denton, R., Francis, D. D. (2013). Performance and inflammation outcomes are predicted by different facets of SES. Social Psychological & Personality Science, 5, 301–309. Google Scholar | SAGE Journals | ISI | |
|
Kraus, M. W., Adler, N. E., Chen, T. W. (2013). Is the association of subjective SES and self-rated health confounded by negative mood? An experimental approach. Health Psychology, 32, 138–145. Google Scholar | Crossref | Medline | ISI | |
|
Kraus, M. W., Côté, S., Keltner, D. (2010). Social class, contextualism, and empathic accuracy. Psychological Science, 21, 1716–1723. Google Scholar | SAGE Journals | ISI | |
|
Kraus, M. W., Piff, P. K., Mendoza-Denton, R., Rheinschmidt, M. L., Keltner, D. (2012). Social class, solipsism and contextualism: How the rich are different from the poor. Psychological Review, 119, 546–572. Google Scholar | Crossref | Medline | ISI | |
|
Matthews, K. A., Gallo, L. C. (2010). Psychological perspectives on pathways linking socioeconomic status and physical health. Annual Review of Psychology, 61, 501–530. Google Scholar | |
|
Mendoza-Denton, R., Downey, G., Purdie, V., Davis, A., Pietrzak, J. (2002). Sensitivity to status-based rejection: Implications for African-American students’ college experience. Journal of Personality and Social Psychology, 83, 896–918. doi:10.1037//0022-3514.83.4.896 Google Scholar | Crossref | Medline | ISI | |
|
Miller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., . . . Kobor, M. S. (2009). Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proceedings of the National Academy of Sciences, USA, 106, 14716–14721. Google Scholar | Crossref | Medline | ISI | |
|
Miller, G. E., Chen, E., Parker, K. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959–997. Google Scholar | Crossref | Medline | ISI | |
|
O’Connor, M. F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., . . . Irwin, M. R. (2009). To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers. Brain, Behavior, and Immunity, 23, 887–897. Google Scholar | Crossref | Medline | ISI | |
|
Page-Gould, E., Mendoza-Denton, R., Tropp, L. R. (2008). With a little help from my cross-group friend: Reducing intergroup anxiety through cross-group friendship. Journal of Personality and Social Psychology, 95, 1080–1094. Google Scholar | Crossref | Medline | ISI | |
|
Pollitt, R. A., Rose, K. M., Kaufman, J. S. (2005). Evaluating the evidence for models of life course socioeconomic factors and cardiovascular outcomes: A systematic review. BMC Public Health, 5, Article 7. Retrieved from http://www.biomedcentral.com/1471-2458/5/7 Google Scholar | |
|
Saxton, K. B., John-Henderson, N., Reid, M. W., Francis, D. D. (2011). The social environment and IL-6 in rats and humans. Brain, Behavior, and Immunity, 25, 1617–1625. doi:10.1016/j.bbi.2011.05.010 Google Scholar | Crossref | Medline | ISI | |
|
Shonkoff, J. P., Boyce, T. W., McEwen, B. S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: Building a new framework for health promotion and disease prevention. Journal of the American Medical Association, 21, 2252–2259. Google Scholar | Crossref | ISI | |
|
Singh-Manoux, A., Marmot, M. G., Adler, N. E. (2005). Does subjective social status predict health and health change better than objective status? Psychosomatic Medicine, 67, 855–861. Google Scholar | Crossref | Medline | ISI | |
|
Slavich, G. M., Way, B. M., Eisenberger, N. I., Taylor, S. E. (2010). Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proceedings of the National Academy of Sciences, USA, 107, 14817–14822. doi:10.1073/pnas.1009164107 Google Scholar | Crossref | Medline | ISI | |
|
Stellar, J. E., Manzo, V., Kraus, M. W., Keltner, D. (2012). Class and compassion: Socioeconomic factors predict responses to suffering. Emotion, 12, 449–459. Google Scholar | Crossref | Medline | ISI | |
|
Stephens, N. M., Fryberg, S. A., Markus, H. R. (2011). When choice does not equal freedom: A sociocultural analysis of agency in working-class contexts. Social Psychological & Personality Science, 2, 33–41. Google Scholar | SAGE Journals | ISI | |
|
Steptoe, A., Hamer, M., Chida, Y. (2007). The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis. Brain, Behavior, and Immunity, 21, 901–912. Google Scholar | Crossref | Medline | ISI | |
|
Yanagisawa, K., Masui, K., Furutani, K., Nomura, M., Yoshida, H., Ura, M. (2013). Family socioeconomic status modulates the coping-related neural response of offspring. Social Cognitive and Affective Neuroscience, 8, 617–622. Google Scholar | Crossref | Medline | ISI |
