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First published online November 7, 2011

TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from Southern Brazil

BP dos Santos, JV Valverde, P Rohr, OA Monticielo, JCT Brenol, RM Xavier, and JAB Chies [email protected]View all authors and affiliations

Volume 21, Issue 3

https://doi.org/10.1177/0961203311425522

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease and can affect several organs and systems. It is characterized by high production of autoantibodies against nuclear compounds. TLR7/8/9 are responsible for nucleic acid recognition and they trigger proinflammatory responses through activation of NK-kappaB and Type I IFN production, making a bridge between the innate and the adaptative immune systems. We analyzed the frequency of TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 and rs352140 in 370 patients with SLE and 415 healthy controls from southern Brazil. All analyses were conducted with regard to gender and ethnicity. Genotypic and allelic frequencies were different for TLR7 rs179008 (0.253 vs. 0.163, p = 0.020 and p = 0.003, OR for T allele: 1.74 CI 95% 1.12–2.70) and TLR9 rs5743836 (0.174 vs. 0.112, p = 0.045 and p = 0.017, OR for C allele: 1.59, CI 95% 0.99–2.57) between European-derived female groups. A higher frequency was observed for the presence of Anti-SSa/Ro for TRL9 rs5743836 C allele carriers (0.228 vs 0.126, Bonferroni corrected p = 0.06). No statistical differences were found for TLR9 haplotypic analyses. We suggest that TLR7 rs179008 and TLR9 rs5743836 can be considered SLE susceptibility factors for women of European descent in our population.

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Volume 21, Issue 3

Pages: 302 - 309

Article first published online: November 7, 2011

Issue published: March 2012

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PubMed: 22065095

Authors

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BP dos Santos

Laboratory of Immunogenetics, Department of Genetics, Universidade Federal do Rio Grande do Sul, Brazil;

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JV Valverde

Laboratory of Immunogenetics, Department of Genetics, Universidade Federal do Rio Grande do Sul, Brazil;

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P Rohr

Laboratory of Immunogenetics, Department of Genetics, Universidade Federal do Rio Grande do Sul, Brazil;

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OA Monticielo

Division of Rheumatology, Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil;

Department of Internal Medicine, Universidade Federal de Santa Maria, Brazil

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JCT Brenol

Division of Rheumatology, Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil;

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RM Xavier

Division of Rheumatology, Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil;

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JAB Chies

Laboratory of Immunogenetics, Department of Genetics, Universidade Federal do Rio Grande do Sul, Brazil;

[email protected]

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Notes

Correspondence to: José Artur Bogo Chies, Universidade Federal do Rio Grande do Sul, Departamento de Genética, Instituto de Biociências, Av. Bento Gonçalves 9500 - Prédio 43323 - Lab. 212, CEP 91501-970, Agronomia - Porto Alegre, RS – Brasil Email: [email protected]

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