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International Journal of Surgical Pathology

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First published online April 1, 2008

Breast Carcinoma With Micropapillary Features: Clinicopathologic Study and Long-Term Follow-Up of 100 Cases

Ling Chen, MD, Yu Fan, MD, Rong-gang Lang, MD, Xiao-jing Guo, MD, Yu-lan Sun, MD, Li-fang Cui, MD, Fang-fang Liu, MD, Jia Wei, MD, Xin-min Zhang, MD, and Li Fu, MD, PhDView all authors and affiliations

Volume 16, Issue 2

https://doi.org/10.1177/1066896907307047

Abstract

To study the clinicopathologic characteristics and prognosis of invasive micropapillary carcinoma of breast (IMPC), 100 cases of invasive breast carcinoma with an IMPC component were reviewed. Compared with invasive ductal carcinoma, not otherwise specified, with similar histologic grades, carcinomas with IMPC were larger sized, had a higher lymph node metastasis rate with more nodes involved per case, and exhibited increased lymphovascular invasion. The presence of IMPC strongly correlated with the more aggressive behavior. No significant association was established between the proportion of the IMPC component and overall tumor size, histologic grade, lymph node metastasis rate, and distant metastasis, but a trend was noted. Long-term follow-up demonstrated a poorer 5-year and 10-year survival rate for patients with breast carcinoma containing an IMPC component. Breast carcinomas with micropapillary features are more aggressive tumors with a poorer prognosis. This specific structure should be carefully evaluated in the surgical pathology examination of breast carcinoma specimens.

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Published In

International Journal of Surgical Pathology

Volume 16, Issue 2

Pages: 155 - 163

Article first published online: April 1, 2008

Issue published: April 2008

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PubMed: 18417672