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1. Guilford, P , Hopkins, J , Harraway, J. E-cadherin germline mutations in familial gastric cancer. Nature. 1998; 392: 402405.
Google Scholar | Crossref | Medline | ISI
2. Caldas, C , Carneiro, F , Lynch, HT. Familial gastric cancer: overview and guidelines for management. J Med Genet. 1999; 36: 873880.
Google Scholar | Medline
3. Fitzgerald, RC , Hardwick, R , Huntsman, D , Carneiro, F , Guilford, P , Blair, V. (on behalf of the International Gastric Cancer Linkage Consortium). Hereditary diffuse gastric cancer: Updated consensus guidelines for clinical management and directions for future research. J Med Genet (in press, 2010).
Google Scholar | Crossref | Medline
4. Guilford, PJ , Hopkins, JB , Grady, WM. E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Hum Mutat. 1999; 14: 249255.
Google Scholar | Crossref | Medline | ISI
5. Richards, FM , McKee, SA , Rajpar, MH. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum Mol Genet. 1999; 8: 607610.
Google Scholar | Crossref | Medline
6. Huntsman, DG , Carneiro, F , Lewis, FR. Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. N Engl J Med. 2001; 344: 19041909.
Google Scholar | Crossref | Medline
7. Caldas, C , Carneiro, F , Lynch, HT. Familial gastric cancer: overview and guidelines for management. J Med Genet. 1999; 36: 873880.
Google Scholar | Medline
8. Blair, V , Martin, I , Shaw, D. Hereditary diffuse gastric cancer: diagnosis and management. Clin Gastroenterol Hepatol. 2006; 4: 262275.
Google Scholar | Crossref | Medline
9. Oliveira, C , Senz, J , Kaurah, P. Germline CDH1 deletions in hereditary diffuse gastric cancer families. Hum Mol Genet. 2009; 18: 15451555.
Google Scholar | Crossref | Medline
10. Oliveira, C , Seruca, R , Carneiro, F . Hereditary gastric cancer. Best Pract Res Clin Gastroenterol. 2009; 23: 147157.
Google Scholar | Crossref | Medline
11. Kaurah, P , MacMillan, A , Boyd, N. Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA. 2007; 297: 23602372.
Google Scholar | Crossref | Medline | ISI
12. Carneiro, F , Oliveira, C , Suriano, G , Seruca, R . Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. J Clin Pathol. 2008; 61: 2530.
Google Scholar | Crossref | Medline
13. Suriano, G , Oliveira, MJ , Huntsman, D. E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells. Hum Mol Genet. 2003; 12: 30073016.
Google Scholar | Crossref | Medline
14. Grady, WM , Willis, J , Guilford, PJ. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nat Genet. 2000; 26: 1617.
Google Scholar | Crossref | Medline | ISI
15. Oliveira, C , Sousa, S , Pinheiro, H. Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroen-terology. 2009; 136: 21372148.
Google Scholar | Crossref | Medline
16. Barber, M , Murrell, A , Ito, Y. Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer. J Pathol. 2008; 216: 295306.
Google Scholar | Crossref | Medline
17. Oliveira, C , de Bruin, J , Nabais, S. Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in a HDGC tumour. Oncogene, 2004; 23: 22362240.
Google Scholar | Crossref | Medline
18. Humar, B , Fukuzawa, R , Blair, V. Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. Cancer Res. 2007; 67: 24802489.
Google Scholar | Crossref | Medline
19. Oliveira, C , Ferreira, P , Nabais, S. E-cadherin (CDH1) and TP53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. Eur J Cancer. 2004; 40: 18971903.
Google Scholar | Crossref | Medline
20. Keller, G , Vogelsang, H , Becker, I. Germline mutations of the E-cadherin (CDH1) and TP53 genes rather than of RUNX3 and HPP1 contribute to genetic predisposition in German gastric cancer patients. J Med Genet. 2004; 41: e89.
Google Scholar | Crossref | Medline
21. Shaw, D , Blair, V , Framp, A. Chromoendoscopic surveillance in hereditary diffuse gastric cancer: an alternative to prophylactic gastrectomy? Gut. 2005; 54: 461468.
Google Scholar | Crossref | Medline
22. Chun, YS , Lindor, NM , Smyrk, TC. Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated? Cancer. 2001; 92: 181187.
Google Scholar | Crossref | Medline
23. Charlton, A , Blair, V , Shaw, D , Parry, S , Guilford, P , Martin, IG . Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut 2004; 53: 814820.
Google Scholar | Crossref | Medline
24. Carneiro, F , Huntsman, DG , Smyrk, TC. Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening. J Pathol. 2004; 203: 681687.
Google Scholar | Crossref | Medline | ISI
25. Barber, ME , Save, V , Carneiro, F. Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk. J Pathol. 2008; 216: 286294.
Google Scholar | Crossref | Medline
26. Rogers, WM , Dobo, E , Norton, JA. Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implications. Am J Surg Pathol. 2008; 32: 799809.
Google Scholar | Crossref | Medline
27. Norton, JA , Ham, CM , Van Dam, J. CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. Ann Surg. 2007; 245: 873879.
Google Scholar | Crossref | Medline
28. Hebbard, PC , Macmillan, A , Huntsman, D. Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. Ann Surg Oncol. 2009; 16: 18901895.
Google Scholar | Crossref | Medline
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