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Abstract
The rare reports of primary, nonneuroendocrine small cell carcinomas of the thyroid have not provided enough evidence to support the recognition of these tumors as an entity or to understand their etiopathogenesis. We report the second case of a primary, nonneuroendocrine small cell carcinoma of the thyroid displaying diffuse expression of cytokeratins, CD99, and p63, in the absence of vimentin expression, in a 24-year-old male who is alive without any signs of disease 13 years after total thyroidectomy and radioactive iodine. The tumor disclosed the EWSR1-FLI1 rearrangement, and we propose to designate it as a carcinoma of the thyroid with Ewing family tumor elements.
References
| 1. |
Meissner, W, Warren, S. Tumors of the thyroid gland. In: Thackray, AC, Lucas, RB, eds. Atlas of Tumor Pathology. 2nd Series, Fasc 4. Washington, DC: Armed Forces Institute of Pathology; 1969:102-105. Google Scholar |
| 2. |
Schmid, K, Kröll, M, Hofstädter, F, Ladurner, D. Small cell carcinoma of the thyroid: a reclassification of cases originally diagnosed as small cell carcinomas of the thyroid. Pathol Res Pract. 1986;181:540-543. Google Scholar | Crossref | Medline | ISI |
| 3. |
Rosai, J, Saxén, E, Woolner, L. Undifferentiated and poorly differentiated carcinoma. Semin Diagn Pathol. 1985;2:123-136. Google Scholar | Medline | ISI |
| 4. |
Kumar, M, Gupta, P, Chaubey, A. The thyroid: an extremely rare primary site of neuroblastoma. Hum Pathol. 2006;37:1357-1360. Google Scholar | Crossref | Medline | ISI |
| 5. |
Biswas, G, Hingmire, S, Bagwan, IN. Primitive neuroectodermal tumour (PNET) of thyroid. Oral Oncol. 2006;42:198-199. Google Scholar | Crossref |
| 6. |
Adapa, P, Chung, TW, Popek, EJ, Hunter, JV. Extraosseous Ewing sarcoma of the thyroid gland. Pediatr Radiol. 2009;39:1365-1368. Google Scholar | Crossref | Medline | ISI |
| 7. |
Maldi, E, Monga, G, Rossi, D, Tosoni, A, Mezzapelle, R, Boldorini, R. Extra-osseous Ewing sarcoma of the thyroid gland mimicking lymphoma recurrence: a case report. Pathol Res Pract. 2012;208:356-359. Google Scholar | Crossref | Medline | ISI |
| 8. |
Stoll, L, Mudali, S, Ali, SZ. Merkel cell carcinoma metastatic to the thyroid gland: aspiration findings and differential diagnosis. Diagn Cytopathol. 2010;38:754-757. Google Scholar | Medline | ISI |
| 9. |
Beach, DF, Klump, WJ, Haddad, G, Reid, LM, Schwarting, R, Hageboutros, A. Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. Med Oncol. 2011;29:1405-1408. Google Scholar | Crossref | Medline | ISI |
| 10. |
Eusebi, V, Damiani, S, Riva, C, Lloyd, RV, Capella, C. Calcitonin free oat-cell carcinoma of the thyroid gland. Virchows Arch A Pathol Anat Histopathol. 1990;417:267-271. Google Scholar | Crossref | Medline |
| 11. |
Luna, M, Mackay, B, Hill, C, Hussey, D, Hickey, R. The quarterly case: malignant small cell tumor of the thyroid. Ultrastruct Pathol. 1980;1:265-270. Google Scholar | Crossref | Medline | ISI |
| 12. |
Cruz, J, Eloy, C, Aragüés, JM, Vinagre, J, Sobrinho-Simões, M. Small-cell (basaloid) thyroid carcinoma: a neoplasm with a solid cell nest histogenesis? Int J Surg Pathol. 2011;19:620-626. Google Scholar | SAGE Journals | ISI |
| 13. |
Schuetz, AN, Rubin, BP, Goldblum, JR. Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation. Mod Pathol. 2005;18:1403-1410. Google Scholar | Crossref | Medline | ISI |
| 14. |
Machado, I, Navarro, S, López-Guerrero, JA, Alberghini, M, Picci, P, Llombart-Bosch, A. Epithelial marker expression does not rule out a diagnosis of Ewing’s sarcoma family of tumours. Virchows Arch. 2011;459:409-414. Google Scholar | Crossref | Medline | ISI |
| 15. |
Weinreb, I, Goldstein, D, Perez-Ordoñez, B. Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. Am J Surg Pathol. 2008;32:1742-1748. Google Scholar | Crossref | Medline | ISI |
| 16. |
Chung, CH, Wang, CH, Wang, TY, Huang, JK, Leu, YS. Extraskeletal Ewing sarcoma mimicking a thyroid nodule. Thyroid. 2006;16:1065-1066. Google Scholar | Crossref | Medline | ISI |
| 17. |
Romeo, S, Dei Tos, AP. Soft tissue tumors associated with EWSR1 translocation. Virchows Arch. 2010;456:219-234. Google Scholar | Crossref | Medline | ISI |
| 18. |
Sirvent, N, Trassard, M, Ebran, N, Attias, R, Pedeutour, F. Fusion of EWSR1 with the DUX4 facioscapulohumeral muscular dystrophy region resulting from t(4;22)(q35;q12) in a case of embryonal rhabdomyosarcoma. Cancer Genet Cytogenet. 2009;195:12-18. Google Scholar | Crossref | Medline |
| 19. |
Brandal, P, Panagopoulos, I, Bjerkehagen, B. Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma. Genes Chromosomes Cancer. 2008;47:558-564. Google Scholar | Crossref | Medline | ISI |
| 20. |
Möller, E, Stenman, G, Mandahl, N. POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol. 2008;215:78-86. Google Scholar | Crossref | Medline | ISI |
| 21. |
Jin, R, Craddock, KJ, Irish, JC, Perez-Ordonez, B, Weinreb, I. Recurrent hyalinizing clear cell carcinoma of the base of tongue with high-grade transformation and EWSR1 gene rearrangement by FISH. Head Neck Pathol. 2012;6:389-394. Google Scholar | Crossref | Medline |
| 22. |
Malone, VS, Dobin, SM, Jones, KA, Donner, LR. CD99-positive large cell neuroendocrine carcinoma with rearranged EWSR1 gene in an infant: a case of prognostically favorable tumor. Virchows Arch. 2010;457:389-395. Google Scholar | Crossref | Medline | ISI |
| 23. |
Bishop, JA, Westra, WH. Human papillomavirus-related small cell carcinoma of the oropharynx. Am J Surg Pathol. 2011;35:1679-1684. Google Scholar | Crossref | Medline | ISI |
| 24. |
Weiss, SW, Goldblum, JR. Enzinger and Weiss’s Soft Tissue Tumors. 5th ed. St Louis, MO: Mosby; 2008. Google Scholar |
