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Abstract
The small cell group of thyroid tumors that includes lymphoma, poorly differentiated carcinoma, medullary carcinoma, secondary neoplasms, as well as tumors with uncertain histogenesis, remains as a valid diagnostic cul-de-sac due to its heterogeneous constitution. The existence of small cell thyroid tumors with EWSR1-FLI1 rearrangement together with neuroendocrine and/or carcinomatous differentiation raises not only differential diagnostic problems but also a very interesting therapeutic dilemma. This review explores the classification of small cell tumors of the thyroid taking into account the immunophenotype and molecular profile of such tumors.
References
| 1. |
Gonçalves, V, Sousa-Lé, Magalhães, M, Sobrinho-Simões, M. Ultrastructure of two small-cell carcinomas of the thyroid gland. J Submicr Cytol. 1978;10:457-463. Google Scholar |
| 2. |
Kumar, M, Gupta, P, Chaubey, A. The thyroid: an extremely rare primary site of neuroblastoma. Hum Pathol. 2006;37:1357-1360. Google Scholar | Crossref | Medline | ISI |
| 3. |
Eloy, C, Vinagre, J, Cameselle-Teijeiro, J, Paiva, ME, Soares, P, Sobrinho-Simões, M. Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component? Int J Surg Pathol. 2011;19:276-280. Google Scholar | SAGE Journals | ISI |
| 4. |
Eloy, C, Oliveira, M, Vieira, J, Teixeira, MR, Cruz, J, Sobrinho-Simões, M. Carcinoma of the thyroid with Ewing family tumor elements and favorable prognosis: report of a second case [published online May 1, 2013]. Int J Surg Pathol. doi:10.1177/1066896913486696. Google Scholar | SAGE Journals | ISI |
| 5. |
Eloy, C, Cruz, J, Vieira, J, Teixeira, MR, Cameselle-Teijeiro, J, Sobrinho-Simões, M. Carcinoma of the thyroid with Ewing family tumor elements: a tumor with unknown histogenesis [published online May 1, 2013]. Int J Surg Pathol. doi:10.1177/1066896913486697. Google Scholar | SAGE Journals | ISI |
| 6. |
Chan, JM, Bilodeau, E, Celin, S, Nikiforov, Y, Johnson, JT. Ewing sarcoma of the thyroid: report of 2 cases and review of the literature. Head Neck. 2013;35:E346-E350. Google Scholar | Crossref | Medline | ISI |
| 7. |
Machado, I, Navarro, S, Lopez-Guerrero, JA, Alberghini, M, Picci, P, Llombart-Bosch, A. Epithelial marker expression does not rule out a diagnosis of Ewing’s sarcoma family of tumours. Virchows Arch. 2011;459:409-414. Google Scholar | Crossref | Medline | ISI |
| 8. |
Cruz, J, Eloy, C, Aragues, JM, Vinagre, J, Sobrinho-Simões, M. Small-cell (basaloid) thyroid carcinoma: a neoplasm with a solid cell nest histogenesis? Int J Surg Pathol. 2011;19:620-626. Google Scholar | SAGE Journals | ISI |
| 9. |
Maldi, E, Monga, G, Rossi, D, Tosoni, A, Mezzapelle, R, Boldorini, R. Extra-osseous Ewing sarcoma of the thyroid gland mimicking lymphoma recurrence: a case report. Pathol Res Pract. 2012;208:356-359. Google Scholar | Crossref | Medline | ISI |
| 10. |
Bishop, JA, Westra, WH. Human papillomavirus-related small cell carcinoma of the oropharynx. Am J Surg Pathol. 2011;35:1679-1684. Google Scholar | Crossref | Medline | ISI |
| 11. |
Pagani, A, Macri, L, Rosolen, A, Toffolatti, L, Stella, A, Bussolati, G. Neuroendocrine differentiation in Ewing’s sarcomas and primitive neuroectodermal tumors revealed by reverse transcriptase-polymerase chain reaction of chromogranin mRNA. Diagn Mol Pathol. 1998;7:36-43. Google Scholar | Crossref | Medline |
| 12. |
Beach, DF, Klump, WJ, Haddad, G, Reid, LM, Schwarting, R, Hageboutros, A. Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. Med Oncol. 2012;29:1405-1408. Google Scholar | Crossref | Medline | ISI |
| 13. |
Eusebi, V, Damiani, S, Riva, C, Lloyd, RV, Capella, C. Calcitonin free oat-cell carcinoma of the thyroid gland. Virchows Arch A Pathol Anat Histopathol. 1990;417:267-271. Google Scholar | Crossref | Medline |
| 14. |
Matias-Guiu, X, LaGuette, J, Puras-Gil, AM, Rosai, J. Metastatic neuroendocrine tumors to the thyroid gland mimicking medullary carcinoma: a pathologic and immunohistochemical study of six cases. Am J Surg Pathol. 1997;21:754-762. Google Scholar | Crossref | Medline | ISI |
| 15. |
Cameselle-Teijeiro, J, Menasce, LP, Yap, BK. Cribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior. Am J Clin Pathol. 2009;131:134-142. Google Scholar | Crossref | Medline | ISI |
| 16. |
Yamazaki, M, Fujii, S, Daiko, H, Hayashi, R, Ochiai, A. Carcinoma showing thymus-like differentiation (CASTLE) with neuroendocrine differentiation. Pathol Int. 2008;58:775-779. Google Scholar | Crossref | Medline | ISI |
