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First published online February 19, 2016

Sensory Gating Capacity and Attentional Function in Adults With ADHD: A Preliminary Neurophysiological and Neuropsychological Study

Abstract

Objective: The inability to filter sensory input correctly may impair higher cognitive function in ADHD. However, this relationship remains largely elusive. The objectives of the present study is to investigate the relationship between sensory input processing and cognitive function in adult patients with ADHD. Method: This study investigated the relationship between deficit in sensory gating capacity (P50 amplitude changes in a double-click conditioning-testing paradigm and perceptual abnormalities related to sensory gating deficit with the Sensory Gating Inventory [SGI]) and attentional and executive function (P300 amplitude in an oddball paradigm and attentional and executive performances with a neuropsychological test) in 24 adult patients with ADHD. Results: The lower the sensory gating capacity of the brain and the higher the distractibility related to sensory gating inability that the patients reported, the lower the P300 amplitude. Conclusion: The capacity of the brain to gate the response to irrelevant incoming sensory input may be a fundamental protective mechanism that prevents the flooding of higher brain structures with irrelevant information in adult patients with ADHD.

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Biographies

Jean-Arthur Micoulaud-Franchi is a medical doctor specialized in Psychiatry, Neurophysiology and Sleep Medicine in the sleep clinic at Bordeaux University Hospital. He received his PhD degree from Aix-Marseille University. His research addresses the link between neurophysiology, sleep and health perception in mental disorders at the USR CNRS 3413 SANSPY.
Régis Lopez is a medical doctor specialized in Psychiatry and Sleep Medicine in the Departement of sleep medicine at Montpellier University Hospital. His research addresses the link between hypersomnolence and ADHD at the Inserm U1061.
Michel Cermolacce is a psychiatrist. He received his PhD degree from Aix-Marseille University. His research is focused on Event Related Potential in mental disorders such as schizophrenia, depression and bipolar disorder.
Florence Vaillant is a licensed psychologist in the Department of Psychiatry at La Conception University Hospital, Marseille.
Pauline Péri is a licensed psychologist in the Department of Psychiatry at La Conception University Hospital, Marseille.
Laurent Boyer is a medical doctor specialized in Public Health, Epidemiology and Biostatistics at the Public Health and Epidemiology department of Aix-Marseille University. His research addresses the problem of quality of life in chronic diseases including mental disorders such as schizophrenia, depression and bipolar disorder.
Raphaëlle Richieri received her MD and PhD degrees from Aix-Marseille University. She is a psychiatrist for adults and researcher in neuromodulation.
Stéphanie Bioulac is currently hospital practitioner in child and adolescent psychiatry department, Charles Perrens Hospital (Bordeaux, France). She is also responsible for the inpatient university unit for child and adolescent (University Hospital of Bordeaux). She conducts a specific outpatient for ADHD. She is PhD in Neurosciences and member of the USR CNRS 3413 SANSPY.
Patricia Sagaspe is a researcher specialized in the field of cognition in the USR CNRS 3413 SANSPY-University of Bordeaux. She received her PhD degree from University of Bordeaux and is a licensed psychologist.
Pierre Philip is a professor in the the sleep clinic at Bordeaux University Hospital. He is head of a CNRS research unit named sleep attention and neuropsychiatric disorders (USR CNRS 3413 SANSPY). He has vast experience in clinical research and is currently coordinator of clinical research for the University Hospital of Bordeaux. His research addresses the link between sleepiness, sleep disorders and mental disorders.
Jean Vion-Dury, MD, PhD, is an assistant-professor at the medical school of Marseille (Aix Marseille University) France, and Head of the Neurophysiology, psychophysiology and neurophenomenology unit of the Psychiatry department of Assistance Publique - Hopitaux de Marseille.
Christophe Lancon is a professor of Psychiatry and Addictology in the Department of Psychiatry at La Conception University Hospital, Marseille. His research addresses the problem of health perception in mental disorders at the Public Health and Epidemiology department of Aix-Marseille University.

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Published In

Article first published online: February 19, 2016
Issue published: August 2019

Keywords

  1. ADHD
  2. adult
  3. sensory gating
  4. P50 suppression
  5. P300
  6. attentional function

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History

Published online: February 19, 2016
Issue published: August 2019
PubMed: 26896149

Authors

Affiliations

Jean-Arthur Micoulaud-Franchi
Clinique du sommeil, CHU de Bordeaux, France
USR CNRS 3113 SANPSY / Université de Bordeaux, France
Régis Lopez
Unités des troubles du sommeil, Hôpital Gui-de-Chauliac Montpellier, France
Inserm U1061, Montpellier, France
Michel Cermolacce
Département de Psychiatrie, CHU de Marseille, France
UMR CNRS 729 / Aix-Marseille Université, Marseille, France
Florence Vaillant
Département de Psychiatrie, CHU de Marseille, France
Pauline Péri
Département de Psychiatrie, CHU de Marseille, France
Laurent Boyer
Département de Psychiatrie, CHU de Marseille, France
EA 3279 / Aix-Marseille Université, Marseille, France
Raphaëlle Richieri
Département de Psychiatrie, CHU de Marseille, France
EA 3279 / Aix-Marseille Université, Marseille, France
Stéphanie Bioulac
USR CNRS 3113 SANPSY / Université de Bordeaux, France
Pôle Universitaire de Psychiatrie de l’Enfant et de l’Adolescent, Bordeaux, France
Patricia Sagaspe
USR CNRS 3113 SANPSY / Université de Bordeaux, France
Pierre Philip
Clinique du sommeil, CHU de Bordeaux, France
USR CNRS 3113 SANPSY / Université de Bordeaux, France
Jean Vion-Dury
Département de Psychiatrie, CHU de Marseille, France
UMR CNRS 729 / Aix-Marseille Université, Marseille, France
Christophe Lancon
Département de Psychiatrie, CHU de Marseille, France
EA 3279 / Aix-Marseille Université, Marseille, France

Notes

Jean-Arthur Micoulaud-Franchi, Services d’explorations fonctionnelles du système nerveux, Clinique du sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France. Email: [email protected]

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