Methodological Issues of Postoperative Cognitive Dysfunction Research
Abstract
Postoperative cognitive dysfunction (POCD) is a subtle impairment of memory, concentration, and speed of information processing. It is a frequent complication following surgery and can have a debilitating effect on patients’ recovery and future prognosis. Neuropsychological testing is needed to reveal postoperative cognitive decline, and questionnaires are not useful for this purpose. There is a profound lack of consensus regarding the research methodology for detection of cognitive deterioration, especially the diagnostic criteria. Issues, such as baseline performance, learning effects, and the interval between test sessions, also influence test results and must be considered when designing and interpreting POCD data.
Get full access to this article
View all access and purchase options for this article.
References
Steinmetz J., Christensen KB, Lund T., Lohse N., Rasmussen LS; Ispocd Group. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009 ;110:548-555.
Bruchiel KJ, Stockard JJ, Calverley RK, et al. Electroencephalographic abnormalities following halothane anesthesia . Anesth Analg. 1978;57:244-251.
Sieber FE Postoperative delirium in the elderly surgical patient. Anesthesiol Clin. 2009;27:451-464.
WHO. ICD-10 classifications of mental and behavioral disorders. http://www.who.int/classifications/icd/en/GRNBOOK.pdf. Accessed January 22, 2010.
Rasmussen LS, Larsen K., Houx P., Skovgaard LT, Hanning CD, Moller JT The assessment of postoperative cognitive function. Acta Anaesthesiol Scand . 2001;45:275-289.
Rabbitt P., Abson V. " Lost and Found": Some logical and methodological limitations of self-report questionnaires as tools to study cognitive ageing. Br J Psychol . 1990;81:1-16.
Newman S., Klinger L., Venn G. et al. Subjective reports of cognition in relation to assessed cognitive performance following coronary artery bypass surgery. J Psychosom Res. 1989;33:227-233.
Johnson T., Monk T., Rasmussen LS, et al; ISPOCD2 Investigators. Postoperative cognitive dysfunction in middle-aged patients. Anesthesiology. 2002 ;96:1351-1357.
Sauër AM, Kalkman C., van Dijk D. Postoperative cognitive decline. J Anesth. 2009;23:256-259.
Silverstein JH, Steinmetz J., Reichenberg A., Harvey PD, Rasmussen LS Postoperative cognitive dysfunction in patients with preoperative cognitive impairment: which domains are most vulnerable ? Anesthesiology. 2007;106:431-435.
Perks A., Chakravarti S., Manninen P. Preoperative anxiety in neurosurgical patients. J Neurosurg Anesthesiol. 2009; 21:127-130.
Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery . Anesthesiology. 2008;108:18-30.
Wang Y., Sands LP, Vaurio L., Mullen EA, Leung JM The effects of postoperative pain and its management on postoperative cognitive dysfunction. Am J Geriatr Psychiatry. 2007 ;15:50-59.
Moller JT, Cluitmans P., Rasmussen LS, et al. Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. Lancet. 1998;351:857-861.
Newman MF, Kirchner JL, Phillips-Bute B., et al. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med. 2001;344:395-402.
Ancelin ML, Roquefeuil GD, Ledésert B., et al. Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology. Br J Psychiatry. 2001;178:360-366.
Cite article
Cite article
Cite article
OR
Download to reference manager
If you have citation software installed, you can download article citation data to the citation manager of your choice
Information, rights and permissions
Information
Published In
Article first published online: May 17, 2010
Issue published: June 2010
Keywords
History
Published online: May 17, 2010
Issue published: June 2010
PubMed: 20478952
Authors
Metrics and citations
Metrics
Journals metrics
This article was published in Seminars in Cardiothoracic and Vascular Anesthesia.
VIEW ALL JOURNAL METRICSArticle usage*
Total views and downloads: 185
*Article usage tracking started in December 2016
Articles citing this one
Web of Science: 0
Crossref: 46
- Association Between Postoperative Delirium and Long-Term Subjective Co...
- Plasma microRNA-221-3p as a biomarker for POCD after non-cardiac surge...
- Effectiveness of cognitive interventions for adult surgical patients a...
- Predictors of cognitive dysfunction after cardiac surgery: a systemati...
- Postoperative cognitive dysfunction: what does it really mean?
- Assessment of a digital game as a neuropsychological test for postoper...
- METTL3 regulates hippocampal gene transcription via N6-methyladenosine...
- Sepsis and Cognitive Assessment
- Time course of dementia following sepsis in German health claims data
- Might complications of analgesic regimen affect cognitive assessment a...
- Assessing postoperative cognitive dysfunction using 3D multiple object...
- Measuring and monitoring cognition in the postoperative period
- The sensitivity and specificity of statistical rules for diagnosing de...
- Characterization of DNA hydroxymethylation in the hypothalamus of elde...
- Effects of Memantine in a Mouse Model of Postoperative Cognitive Dysfu...
- Postoperative cognitive dysfunction in noncardiac surgery: A review
- Efeitos das alterações no oxigênio cerebral durante cirurgia de revasc...
- Effects of cerebral oxygen changes during coronary bypass surgery on p...
- Exploring Postoperative Cognitive Dysfunction and Delirium in Noncardi...
- The effect of desflurane versus propofol anesthesia on postoperative d...
- Efeito de dois protocolos de controle glicêmico diferentes sobre a dis...
- The effect of two different glycemic management protocols on postopera...
- Early post-surgical cognitive dysfunction is a risk factor for mortali...
- Prevention and correction of cognitive dysfunction after general anest...
- The future of postoperative quality of recovery assessment
- O efeito de sugamadex sobre a função cognitiva e recuperação no pós‐op...
- The effect of sugammadex on postoperative cognitive function and recov...
- Short-Term Changes in Postoperative Cognitive Function in Children Age...
- Defining Postoperative Quality of Recovery
- Postoperative recovery and outcomes - what are we measuring and for wh...
- Investigation of one-lung ventilation postoperative cognitive dysfunct...
- Postoperative Cognitive Dysfunction
- Challenges in anaesthesia for elderly
- A review of the scope and measurement of postoperative quality of reco...
- Serum Anticholinergic Activity and Postoperative Cognitive Dysfunction...
- The Anesthesia Perspective
- Should general anaesthesia be avoided in the elderly?
- Hereditary vulnerabilities to post-operative cognitive dysfunction and...
- A Human Volunteer Study to Identify Variability in Performance in the ...
- How Can We Prevent Postoperative Cognitive Dysfunction?
- Thinking through postoperative cognitive dysfunction: How to bridge th...
- Clinical, methodological and theoretical issues in the assessment of c...
- Postoperative cognitive dysfunction in geriatric patients
- Circulatory arrest versus cerebral perfusion during pulmonary endarter...
- Postoperative cognitive disorders
- An Update on Postoperative Cognitive Dysfunction
Figures and tables
Figures & Media
Tables
View Options
Get access
Access options
If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below:
loading institutional access options
Alternatively, view purchase options below:
Purchase 24 hour online access to view and download content.
Access journal content via a DeepDyve subscription or find out more about this option.
