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First published online August 25, 2010

Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6

Akiyuki Uzawa, Masahiro Mori, Kimihito Arai, Yasunori Sato, Sei Hayakawa, Saeko Masuda, Junko Taniguchi, and Satoshi KuwabaraView all authors and affiliations
Volume 16, Issue 12
https://doi.org/10.1177/1352458510379247

Abstract

Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking.
Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO.
Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined.
Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers.
Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO.

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Information

Published In

Volume 16, Issue 12
Pages: 1443 - 1452
Article first published online: August 25, 2010
Issue published: December 2010

Keywords

  1. chemokine
  2. cytokine
  3. glial fibrillary acidic protein
  4. immunohistochemical staining
  5. interleukin-6
  6. multiple sclerosis
  7. neuromyelitis optica

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© The Author(s) 2010.
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History

Published online: August 25, 2010
Issue published: December 2010
PubMed: 20739337

Authors

Affiliations

Akiyuki Uzawa
Department of Neurology, Graduate School of Medicine, Chiba University, Japan, [email protected]
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Masahiro Mori
Department of Neurology, Graduate School of Medicine, Chiba University, Japan
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Kimihito Arai
Department of Neurology, Chiba-East National Hospital, Japan
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Yasunori Sato
Clinical Research Center, Chiba University Hospital, Japan
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Sei Hayakawa
Department of Neurology, Graduate School of Medicine, Chiba University, Japan
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Saeko Masuda
Department of Neurology, Graduate School of Medicine, Chiba University, Japan
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Junko Taniguchi
Department of Neurology, Graduate School of Medicine, Chiba University, Japan
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Satoshi Kuwabara
Department of Neurology, Graduate School of Medicine, Chiba University, Japan
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