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First published online January 1, 2008

Review: Vitamin D, immunity and lupus

M. Cutolo and K. OtsaView all authors and affiliations
Volume 17, Issue 1
https://doi.org/10.1177/0961203307085879

Abstract

The identification of vitamin D receptor in cells involved in the immune response and the discovery that activated dendritic cells produce vitamin D hormone suggested that vitamin D could exert immunoregulatory effects. Patients with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus (SLE) show low 25-OH vitamin D serum levels. In particular, SLE patients have multiple risk factors for vitamin D deficiency and disease severity seems correlated with lower 25-OH vitamin D serum levels. Treatment of vitamin D deficiency could be particularly important in SLE patients due to concomitant insults on their tissues such as bone, and in view of the possible immunomodulatory effects exerted by vitamin D. Lupus (2008) 17, 6—10.

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Published In

Volume 17, Issue 1
Pages: 6 - 10
Article first published online: January 1, 2008
Issue published: January 2008

Keywords

  1. immune response
  2. systemic lupus erythematosus
  3. vitamin D

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History

Published online: January 1, 2008
Issue published: January 2008
PubMed: 18089676

Authors

Affiliations

M. Cutolo
Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova Italy, [email protected]
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K. Otsa
Department of Rheumatology, Tallinn Central Hospital, Tallinn, Estonia
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