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First published online January 1, 2008

Review: Vitamin D, immunity and lupus

Abstract

The identification of vitamin D receptor in cells involved in the immune response and the discovery that activated dendritic cells produce vitamin D hormone suggested that vitamin D could exert immunoregulatory effects. Patients with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus (SLE) show low 25-OH vitamin D serum levels. In particular, SLE patients have multiple risk factors for vitamin D deficiency and disease severity seems correlated with lower 25-OH vitamin D serum levels. Treatment of vitamin D deficiency could be particularly important in SLE patients due to concomitant insults on their tissues such as bone, and in view of the possible immunomodulatory effects exerted by vitamin D. Lupus (2008) 17, 6—10.

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References

Holick MF Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutrition 2004; 6: 1678S—1688S.
Arnson Y., Amital H., Shoenfeld Y. Vitamin D and autoimmunity: new etiological and therapeutical considerations . Ann Rheum Dis 2007; 66: 1137—1142.
Deluca HF, Cantorna MT Vitamin D: its role and uses in immunology. FASEB J 2001; 15: 2579—2585.
Langub MC, Reinhardt TA, Horst RL et al. Characterization of vitamin D receptor immunoreactivity in human bone cells. Bone 2000; 27: 383—387.
Mahon BD, Wittke A., Weaver V. et al. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 2003; 89: 922—932.
Bhalla AK, Amento EP, Serog B. et al. 1,25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation . J Immunol 1984; 133: 1748—1754.
Lemire JM Immunomodulatory role of 1,25-dihydroxyvitamin D3. J Cell Biochem 1992; 49: 26—31.
Mattner F., Smiroldo S., Galbiati F. et al. Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3). Eur J Immunol 2000; 30: 498—508.
Boonstra A. , Barrat FJ, Crain C. et al. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells . J Immunol 2001; 167: 4974—4980.
van EE, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005; 97: 93—101.
Cantorna MT , Woodward WD, Hayes CE et al. 1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4 . J Immunol 1998; 160: 5314—5319.
Staeva-Vieira TP, Freedman LP 1,25-dihydroxyvitamin D3 inhibits IFNgamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells . J Immunol 2002; 168: 1181—1189.
Xue ML, Zhu H., Thakur A. et al. 1 alpha,25-Dihydroxyvitamin D3 inhibits pro inflammatory cytokine and chemokine expression in human corneal epithelial cells colonized with Pseudomonas aeruginosa 5. Immunol Cell Biol 2002; 80: 340—345.
Stockinger B. Th17 cells: An orphan with influence 4. Immunol Cell Biol 2007; 85: 83—84.
Linker-Israeli M., Elstner E., Klinenberg JR et al. Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC. Clin Immunol 2001; 99: 82—93.
Griffin MD, Lutz W., Phan VA et al. Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci USA 2001; 98: 6800—6805.
Berer A., Stockl J., Majdic O. et al. 1,25-Dihydroxyvitamin D(3) inhibits dendritic cell differentiation and maturation in vitro. Exp Hematol 2000; 28: 575—583.
Penna G., Adorini L. 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 2000; 164: 2405—2411.
Griffin MD, Lutz WH, Phan VA et al. Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs. Biochem Biophys Res Commun 2000; 270: 701—708.
Helming L., Bose J., Ehrchen J. et al. 1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation. Blood 2005; 106: 4351—4358.
Munger KL, Zhang SM, O'Reilly E. et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004; 62: 60—65.
Merlino LA, Curtis J., Mikuls TR et al. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 2004; 50: 72—77.
Cutolo M., Otsa K., Laas K. et al. Circannual vitamin D serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe. Clin Exp Rheumatol 2006; 24: 702—704.
Cantorna MT , Munsick C., Bemiss C. et al. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease . J Nutr 2000; 130: 2648—2652.
Cantorna MT , Mahon BD Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood) 2004; 229: 1136—1142.
Alarcon GS, Friedman AW, Straaton KV et al. Systemic lupus erythematosus in three ethnic groups: III. A comparison of characteristics early in the natural history of the LUMINA cohort. LUpus in MInority populations: Nature vs Nurture. Lupus 1999; 8: 197—209.
Kamen DL, Cooper GS, Bouali H., Shaftman SR, Hollis BW, Gilkeson GS Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev 2006; 5: 114—117.
O'Regan S., Chesney RW, Hamstra A., Eisman JA, O'Gorman AM, DeLuca HF Reduced serum 1,25-(OH)2 vitamin D3 levels in prednisone-treated adolescents with systemic lupus erythematosus. Acta Paediatr Scand 1979; 68: 109—111.
Huisman AM, White KP, Algra A. et al. Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia. J Rheumatol 2001; 28: 2535—2539.
Muller K., Kriegbaum NJ, Baslund B., Sorensen OH, Thymann M., Bentzen K. Vitamin D3 metabolism in patients with rheumatic diseases: low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus. Clin Rheumatol 1995; 14: 397—400.
Abe J., Nakamura K., Takita Y., Nakano T., Irie H., Nishii Y. Prevention of immunological disorders in MRL/l mice by a new synthetic analogue of vitamin D3: 22-oxa-1 alpha,25-dihydroxyvitamin D3. J Nutr Sci Vitaminol (Tokyo) 1990; 36: 21—31.
Barnes TC, Bucknall RC Vitamin D deficiency in a patient with systemic lupus erythematosus. Rheumatology 2004; 43: 393—394.
Klein RG, Arnaud SB, Gallagher JC, Deluca HF, Riggs BL Intestinal calcium absorption in exogenous hypercortisolism. Role of 25-hydroxy vitamin D and corticosteroid dose. J Clin Invest 1977; 60: 253—259.
Hahn TJ, Halstead LR, Haddad JG Jr.Serum 25-hydroxy vitamin D concentrations in patients receiving chronic corticosteroid therapy. J Lab Clin Med 1977; 90: 399—404.
Carre M., Ayigbebe O., Miravet L., Rasmussen H. The effect of prednisolone on the metabolism and action of 25-hydroxy and 1,25- dihydroxyvitamin D. Proc Natl Acad Sci USA 1974; 71: 2996—3000.
O'Leary TJ, Jones G., Yip A., Lohnes D., Cohanim M., Yendt ER The effects of chloroquine on serum 1,25-dihydroxyvitamin D and calcium metabolism in sarcoidosis. N Engl J Med 1986; 315: 727—730.
Carvalho JF , Blank M., Kiss E., Tarr T., Amital H., Shoenfeld Y. Anti-vitamin D, vitamin D in SLE: preliminary results. Ann N Y Acad Sci 2007; 1109: 550—557.
Muller K., Kriegbaum NJ, Baslund B., Sorensen OH, Thyman M., Bentzen K. Vitamin D3 metabolism in patients with rheumatic diseases: low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus. Clin Rheumatol 1995; 14: 397—400.
O'Regan S. , Chesney RW, Hamstra A., Eisman JA, O'Gorman AM, Deluca HF Reduced serum 1,25-(OH)2 vitamin D3 levels in prednisolone-treated adolescents with systemic lupus erythematosus. Acta Paediatr Scand 1979; 68: 109—111.
Redlich K., Ziegler S., Kiener HP et al. Bone mineral density and biochemical parameters of bone metabolism in female patients with systemic lupus erythematosus. Ann Rheum Dis 2000; 59: 308—310.
Deluca HF, Cantorna MT Vitamin D: its role and uses in immunology. FASEB J 2001; 15: 2579—2585.
Costenbader KH , Feskanich D., Benito-Garcia E., Holmes M., Karlson E. Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. Ann Rheum Dis 2007 (Epub ahead of print).
Cutolo M., Otsa K., Yprus M., Seriolo B. Vitamin D and rheumatoid arthritis: comment on the letter by Nielen et al . Arthritis Rheum 2007; 56: 1719—1720.
Cutolo M., Maestroni GJ, Otsa K. et al. Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison. Ann Rheum Dis 2005; 64: 212—216.
Chatfield SM , Brand C., Ebeling PR et al. Vitamin D deficiency in general medical in patients in summer and winter. Intern Med J 2007; 37: 377—382.

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Published In

Article first published online: January 1, 2008
Issue published: January 2008

Keywords

  1. immune response
  2. systemic lupus erythematosus
  3. vitamin D

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History

Published online: January 1, 2008
Issue published: January 2008
PubMed: 18089676

Authors

Affiliations

M. Cutolo
Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova Italy, [email protected]
K. Otsa
Department of Rheumatology, Tallinn Central Hospital, Tallinn, Estonia

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