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Abstract
This study investigated how light exposure duration affects melatonin suppression, a well-established marker of circadian phase, and whether adolescents (13–18 years) are more sensitive to short-wavelength (blue) light than adults (32–51 years). Twenty-four participants (12 adolescents, 12 adults) were exposed to three lighting conditions during successive 4-h study nights that were separated by at least one week. In addition to a dim light (<5 lux) control, participants were exposed to two light spectra (warm (2700 K) and cool (5600 K)) delivering a circadian stimulus of 0.25 at eye level. Repeated measures analysis of variance revealed a significant main effect of exposure duration, indicating that a longer duration exposure suppressed melatonin to a greater degree. The analysis further revealed a significant main effect of spectrum and a significant interaction between spectrum and participant age. For the adolescents, but not the adults, melatonin suppression was significantly greater after exposure to the 5600 K intervention (43%) compared to the 2700 K intervention (29%), suggesting an increased sensitivity to short-wavelength radiation. These results will be used to extend the model of human circadian phototransduction to incorporate factors such as exposure duration and participant age to better predict effective circadian stimulus.
References
| 1. | Figueiro, MG, Bullough, JD, Bierman, A, Rea, MS. Demonstration of additivity failure in human circadian phototransduction. Neuro Endocrinology Letters 2005; 26: 493–498. Google Scholar | Medline | ISI |
| 2. | Figueiro, MG, Bullough, JD, Parsons, RH, Rea, MS. Preliminary evidence for spectral opponency in the suppression of melatonin by light in humans. Neuroreport 2004; 15: 313–316. Google Scholar | Crossref | Medline | ISI |
| 3. | Lockley, SW, Brainard, GC, Czeisler, CA. High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. Journal of Clinical Endocrinology and Metabolism 2003; 88: 4502–4505. Google Scholar | Crossref | Medline | ISI |
| 4. | Morita, T, Teramoto, Y, Tokura, H. Inhibitory effect of light of different wavelengths on the fall of core temperature during the nighttime. Japanese Journal of Physiology 1995; 45: 667–671. Google Scholar | Crossref | Medline |
| 5. | Morita, T, Tokura, H. Effects of lights of different color temperature on the nocturnal changes in core temperature and melatonin in humans. Applied Human Science: Journal of Physiological Anthropology 1996; 15: 243–246. Google Scholar | Crossref | Medline |
| 6. | Rea, MS, Bullough, JD, Figueiro, MG. Human melatonin suppression by light: a case for scotopic efficiency. Neuroscience Letters 2001; 299: 45–48. Google Scholar | Crossref | Medline |
| 7. | Rea, MS, Bullough, JD, Figueiro, MG. Phototransduction for human melatonin suppression. Journal of Pineal Research 2002; 32: 209–213. Google Scholar | Crossref | Medline | ISI |
| 8. | Thapan, K, Arendt, J, Skene, DJ. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. The Journal of Physiology 2001; 535: 261–267. Google Scholar | Crossref | Medline | ISI |
| 9. | Wright, HR, Lack, LC. Effect of light wavelength on suppression and phase delay of the melatonin rhythm. Chronobiology International 2001; 18: 801–808. Google Scholar | Crossref | Medline | ISI |
| 10. | Wright, H, Lack, L, Kennaway, D. Differential effects of light wavelength in phase advancing the melatonin rhythm. Journal of Pineal Research 2004; 36: 140–144. Google Scholar | Crossref | Medline | ISI |
| 11. | Brainard, GC, Lewy, AJ, Menaker, M, Fredrickson, RH, Miller, LS, Weleber, RG, Cassone, V, Hudson, D. Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers. Brain Research 1988; 454: 212–218. Google Scholar | Crossref | Medline | ISI |
| 12. | Brainard, GC, Hanifin, JP, Greeson, JM, Byrne, B, Glickman, G, Gerner, E, Rollag, MD. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. Journal of Neuroscience 2001; 21: 6405–6412. Google Scholar | Crossref | Medline | ISI |
| 13. | Brainard, GC, Richardson, BA, Petterborg, LJ, Reiter, R. The effect of different light intensities on pineal melatonin content. Brain Research 1982; 233: 75–81. Google Scholar | Crossref | Medline | ISI |
| 14. | Rea, MS . IESNA Lighting Handbook: Reference and Application, 9th Edition. New York, NY: Illuminating Engineering Society of North America, 2000. Google Scholar |
| 15. | Reiter, R . Action spectra, dose-response relationships, and temporal aspects of light’s effects on the pineal gland. Annals of the New York Academy of Sciences 1985; 453: 215–230. Google Scholar | Crossref | Medline |
| 16. | Boyce, PR . Human Factors in Lighting, 2nd Edition. New York: Taylor and Francis, Inc., 2003. Google Scholar | Crossref |
| 17. | Figueiro, MG . An overview of the effects of light on human circadian rhythms: implications for new light sources and lighting systems design. Journal of Light and Visual Environment 2013; 37: 51–61. Google Scholar | Crossref |
| 18. | Rea, MS, Figueiro, MG, Bierman, A, Hamner, R. Modelling the spectral sensitivity of the human circadian system. Lighting Research and Technology 2012; 44: 386–396. Google Scholar | SAGE Journals | ISI |
| 19. | Rea, MS, Figueiro, MG. A working threshold for acute nocturnal melatonin suppression from “white” light sources used in architectural applications. Journal of Carcinogenesis and Mutagenesis 2013; 4: 1000150–1000150. Google Scholar |
| 20. | Figueiro, MG, Rea, MS, Bullough, JD. Circadian effectiveness of two polychromatic lights in suppressing human nocturnal melatonin. Neuroscience Letters 2006; 406: 293–297. Google Scholar | Crossref | Medline | ISI |
| 21. | Amundadottir, ML, Lockley, SW, Andersen, M. Unified framework to evaluate non-visual spectral effectiveness of light for human health. Lighting Research and Technology 2017; 49: 673–696. Google Scholar | SAGE Journals | ISI |
| 22. | Barroso, A, Den Brinker, B. Boosting circadian rhythms with lighting: a model driven approach. Lighting Research and Technology 2013; 45: 197–216. Google Scholar | SAGE Journals | ISI |
| 23. | Bellia, L, Seraceni, M. A proposal for a simplified model to evaluate the circadian effects of light sources. Lighting Research and Technology 2014; 46: 493–505. Google Scholar | SAGE Journals | ISI |
| 24. | Enezi, Ja, Revell, V, Brown, T, Wynne, J, Schlangen, L, Lucas, R. A “melanopic” spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights. Journal of Biological Rhythms 2011; 26: 314–323. Google Scholar | SAGE Journals | ISI |
| 25. | Gall D, Bieske K. Definition and measurement of circadian radiometric quantities: Proceedings of the CIE symposium ‘04 on light and health, Vienna, Austria: Commission Internationale de l’Éclairage: 2004: 129–132. Google Scholar |
| 26. | Lucas, RJ, Peirson, SN, Berson, DM, Brown, TM, Cooper, HM, Czeisler, CA, Figueiro, MG, Gamlin, PD, Lockley, SW, O’Hagan, JB, Price, LL, Provencio, I, Skene, DJ, Brainard, GC. Measuring and using light in the melanopsin age. Trends in Neurosciences 2014; 37: 1–9. Google Scholar | Crossref | Medline | ISI |
| 27. | McIntyre, IM, Norman, TR, Burrows, GD, Armstrong, SM. Human melatonin suppression by light is intensity dependent. Journal of Pineal Research 1989; 6: 149–156. Google Scholar | Crossref | Medline | ISI |
| 28. | McIntyre, IM, Norman, TR, Burrows, GD, Armstrong, SM. Quantal melatonin suppression by exposure to low intensity light in man. Life Sciences 1989; 45: 327–332. Google Scholar | Crossref | Medline |
| 29. | Aoki, H, Yamada, N, Ozeki, Y, Yamane, H, Kato, N. Minimum light intensity required to suppress nocturnal melatonin concentration in human saliva. Neuroscience Letters 1998; 252: 91–94. Google Scholar | Crossref | Medline | ISI |
| 30. | Chang, AM, Santhi, N, St Hilaire, M, Gronfier, C, Bradstreet, DS, Duffy, JF, Lockley, SW, Kronauer, RE, Czeisler, CA. Human responses to bright light of different durations. The Journal of Physiology 2012; 590: 3103–3112. Google Scholar | Crossref | Medline | ISI |
| 31. | Dewan, K, Benloucif, S, Reid, K, Wolfe, LF, Zee, PC. Light-induced changes of the circadian clock of humans: increasing duration is more effective than increasing light intensity. Sleep 2011; 34: 593–599. Google Scholar | Crossref | Medline | ISI |
| 32. | St Hilaire, MA, Gooley, JJ, Khalsa, SB, Kronauer, RE, Czeisler, CA, Lockley, SW. Human phase response curve to a 1 h pulse of bright white light. The Journal of Physiology 2012; 590: 3035–3045. Google Scholar | Crossref | Medline | ISI |
| 33. | Khalsa, SB, Jewett, ME, Cajochen, C, Czeisler, CA. A phase response curve to single bright light pulses in human subjects. The Journal of Physiology 2003; 549: 945–952. Google Scholar | Crossref | Medline | ISI |
| 34. | Terman, M, Terman, J. Bright light therapy: side effects and benefits across the symptom spectrum. Journal of Clinical Psychiatry 1999; 60: 799–808. Google Scholar | Medline | ISI |
| 35. | Terman, JS, Terman, M, Schlager, D, Rafferty, B, Rosofsky, M, Link, MJ, Gallin, PF, Quitkin, FM. Efficacy of brief, intense light exposure for treatment of winter depression. Psychopharmacology Bulletin 1990; 26: 3–11. Google Scholar | Medline |
| 36. | Terman, M, Lewy, AJ, Dijk, DJ, Boulos, Z, Eastman, CI, Campbell, SS. Light treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances. Journal of Biological Rhythms 1995; 10: 135–147. Google Scholar | SAGE Journals | ISI |
| 37. | Rea, MS, Figueiro, MG, Bullough, JD, Bierman, A. A model of phototransduction by the human circadian system. Brain Research Reviews 2005; 50: 213–228. Google Scholar | Crossref | Medline |
| 38. | Gooley, JJ, Rajaratnam, SM, Brainard, GC, Kronauer, RE, Czeisler, CA, Lockley, SW. Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light. Science Translational Medicine 2010; 2: 31–33. Google Scholar | Crossref | ISI |
| 39. | Wood, B, Rea, MS, Plitnick, B, Figueiro, MG. Light level and duration of exposure determine the impact of self-luminous tablets on melatonin suppression. Applied Ergonomics 2013; 44: 237–240. Google Scholar | Crossref | Medline | ISI |
| 40. | Figueiro, MG, Overington, D. Self-luminous devices and melatonin suppression in adolescents. Lighting Research and Technology 2016; 48: 966–975. Google Scholar | SAGE Journals | ISI |
| 41. | Crowley, SJ, Acebo, C, Carskadon, MA. Sleep, circadian rhythms, and delayed phase in adolescence. Sleep Medicine 2007; 8: 602–612. Google Scholar | Crossref | Medline | ISI |
| 42. | Crowley, SJ, Carskadon, MA. Modifications to weekend recovery sleep delay circadian phase in older adolescents. Chronobiology International 2010; 27: 1469–1492. Google Scholar | Crossref | Medline | ISI |
| 43. | Costa, IC, Carvalho, HN, Fernandes, L. Aging, circadian rhythms and depressive disorders: a review. American American Journal of Neurodegenerative Disease 2013; 2: 228–246. Google Scholar | Medline |
| 44. | Turek, FW, Penev, P, Zhang, Y, van Reeth, O, P. Z. Effects of age on the circadian system. Neuroscience and Biobehavioral Reviews 1995; 19: 53–58. Google Scholar | Crossref | Medline | ISI |
| 45. | Higuchi, S, Nagafuchi, Y, Lee, S-I, Harada, T. Influence of light at night on melatonin suppression in children. The Journal of Clinical Endocrinology and Metabolism 2014; 99: 3298–3303. Google Scholar | Crossref | Medline |
| 46. | Roenneberg, T, Wirz-Justice, A, Merrow, M. Life between clocks: daily temporal patterns of human chronotypes. Journal of Biological Rhythms 2003; 18: 80–90. Google Scholar | SAGE Journals | ISI |
| 47. | Portaluppi, F, Smolensky, MH, Touitou, Y. Ethics and methods for biological rhythm research on animals and human beings. Chronobiology International 2010; 27: 1911–1929. Google Scholar | Crossref | Medline | ISI |
| 48. | Commission Internationale de l’Éclairage . CIE TN 003:2015 Report on the First International Workshop on Circadian and Neurophysiological Photometry, 2013, Vienna: CIE, 2015. Google Scholar |
| 49. | Commission Internationale de l’Éclairage. Report on the First International Workshop on Circadian and Neurophysiological Photometry, 2013. Vienna: CIE, 2015. Open access downloadable Microsoft Excel version of the CIE’s SI-compatible irradiance toolbox. Retrieved 12 February 2018, from http://files.cie.co.at/784_TN003_Toolbox.xls. Google Scholar |
| 50. | Bullough, JD, Bierman, A, Rea, MS. Evaluating the blue-light hazard from solid state lighting. International Journal of Occupational Safety and Ergonomics. First published 6 October 2017. DOI: 10.1080/10803548.2017.1375172. Google Scholar |
| 51. | Lighting Research Center . Circadian Stimulus Calculator, Troy, NY: Lighting Research Center at Rensselaer Polytechnic Institute, 2017. Open access downloadable Microsoft Excel file for the Lighting Research Center's CS Calculator. Retrieved 9 February 2018, from http://www.lrc.rpi.edu/programs/lightHealth/. Google Scholar |
| 52. | Cohen, J . Statistical Power Analysis for the Behavioral Sciences, 2nd Edition. Hillsdale, NJ: Lawrence Erlbaum Associates, 1988. Google Scholar |
| 53. | Gabel, V, Reichert, CF, Maire, M, Schmidt, C, Schlangen, LJM, Kolodyazhniy, V, Garbazza, C, Cajochen, C, Antoine, UV. Differential impact in young and older individuals of blue-enriched white light on circadian physiology and alertness during sustained wakefulness. Scientific Reports 2017; 7: 7620–7620. Google Scholar | Crossref | Medline |
| 54. | Snodderly, DM, Brown, PK, Delon, FC, Auran, JD. The macular pigment: I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Investigative Ophthalmology and Visual Science 1984; 25: 660–673. Google Scholar | Medline | ISI |
| 55. | Turner, PL, Mainster, MA. Circadian photoreception: ageing and the eye’s important role in systemic health. British Journal of Ophthalmology 2008; 92: 1439–1444. Google Scholar | Crossref | Medline | ISI |
| 56. | Charman, WN . Age, lens transmittance, and the possible effects of light on melatonin suppression. Ophthalmic and Physiological Optics 2003; 23: 181–187. Google Scholar | Crossref | Medline | ISI |
| 57. | Najjar, RP, Chiquet, C, Teikari, P, Cornut, P, Claustrat, B, Denis, P, Cooper, HM, Gronfier, C. Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms? PLoS One 2014; 9: e85837–e85837. Google Scholar | Crossref | Medline |
| 58. | Figueiro, MG, Bierman, A, Rea, MS. Retinal mechanisms determine the subadditive response to polychromatic light by the human circadian system. Neuroscience Letters 2008; 438: 242–245. Google Scholar | Crossref | Medline | ISI |
| 59. | Eliasieh, K, Liets, LC, Chalupa, LM. Cellular reorganization in the human retina during normal aging. Investigative Ophthalmology and Visual Science 2007; 48: 2824–2830. Google Scholar | Crossref | Medline |
| 60. | Hannibal, J, Georg, B, Hindersson, P, Fahrenkrug, J. Light and darkness regulate melanopsin in the retinal ganglion cells of the albino Wistar rat. Journal of Molecular Neuroscience 2005; 27: 147–155. Google Scholar | Crossref | Medline |
| 61. | Wong, KY, Dunn, FA, Berson, DM. Photoreceptor adaptation in intrinsically photosensitive retinal ganglion cells. Neuron 2005; 48: 1001–1010. Google Scholar | Crossref | Medline | ISI |
| 62. | Giannotti, F, Cortesi, F, Sebastiani, T, Ottaviano, S. Circadian preference, sleep and daytime behaviour in adolescence. Journal of Sleep Research 2002; 11: 191–199. Google Scholar | Crossref | Medline | ISI |
| 63. | Russo, PM, Bruni, O, Lucidi, F, Ferri, R, Violani, C. Sleep habits and circadian preference in Italian children and adolescents. Journal of Sleep Research 2007; 16: 163–169. Google Scholar | Crossref | Medline |
