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Abstract
The popular edible mushroom Ganoderma lucidum(Reishi) has been widely used for the general promotion of health and longevity in Asian countries. The dried powder of Ganoderma lucidumwas popular as a cancer chemotherapy agent in ancient China. The authors recently demonstrated thatGanoderma luciduminhibits constitutively active transcription factors nuclear factor kappa B (NF-.B) and AP-1, which resulted in the inhibition of expression of urokinasetype plasminogen activator (uPA) and its receptor uPAR.Ganoderma lucidumalso suppressed cell adhesion and cell migration of highly invasive breast and prostate cancer cells, suggesting its potency to reduce tumor invasiveness. Thus, Ganoderma lucidumclearly demonstrates anticancer activity in experiments with cancer cells and has possible therapeutic potential as a dietary supplement for an alternative therapy for breast and prostate cancer. However, because of the availability of Ganoderma lucidum from different sources, it is advisable to test its biologic activity.
Keywords
| 1.Yun TK. Update from Asia: Asian studies on cancer chemoprevention. Ann N Y Acad Sci. 1999;889:157-192. Google Scholar | Crossref | Medline | ISI | |
| 2. Go VL, Wong DA, Resnick MS, Heber D. Evaluation of botanicals and dietary supplements therapy in cancer patients. J Nutr. 2001;131(1):179S-180S. Google Scholar | Crossref | Medline | ISI | |
| 3. Heber D, Blackburn GL, Go VL. Nutritional Oncology. New York, NY: Academic Press; 1999. Google Scholar | |
| 4. Kim SS, Kim YS. Korean Mushrooms. Seoul: Yupoong; 1990:298-299. Google Scholar | |
| 5. Shiao MS, Lee KR, Lin LJ, Wang CT. Natural products and biological activities of the Chinese medical fungus, Ganoderma lucidum. In: Ho CT, Osawa T, Huang MT, Rosen RT, eds. Food Phytochemicals for Cancer Prevention. II. Teas, Spices, and Herbs. Washington, DC: American Chemical Society; 1994:342-354. Google Scholar | |
| 6. Miyazaki T, Nishijima M. Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. Chem Pharmacol Bull. 1981;29(12):3611-3616. Google Scholar | Crossref | Medline | ISI | |
| 7. Sone Y, Okuda R, Wada N, Kishida E, Misaki A. Structure and antitumor activities of polysaccharides isolated from fruiting body and the growing culture of mycelium of Ganoderma lucidum. Agric Biol Chem. 1985;49:2641-2653. Google Scholar | |
| 8. Yan J, Vetvicka V, Xia Y, Coxon A, Carroll MC, Mayadas TN, Ross GD. Beta-glucan, a “specific” biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). J Immunol. 1999;163(6):3045-3052. Google Scholar | Medline | ISI | |
| 9. Sasaki T, Arai Y, Ikekawa T, Chihara G, Fukuoka F. Antitumor polysaccharides from some polyporaceae, Ganoderma applanatum(Pers.) Pat and Phellinus linteus(Berk. et Curt) Aoshima. Chem Pharm Bull. (Tokyo) 1971;19(4):821-826. Google Scholar | Crossref | Medline | ISI | |
| 10. Nakashima S, Umeda Y, Kanada T. Effect of polysaccharides from Ganoderma applanatumon immune response. I. Enhancing effect on the induction of delayed hypersensitivity in mice. Microbiol Immunol. 1979;23(6):501-513. Google Scholar | Crossref | Medline | ISI | |
| 11. Ukai S, Kiho T, Hara C, et al. Polysaccharides in fungi. XIII. Antitumor activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auricula-judae,and Auriculariaspecies. Chem Pharm Bull. (Tokyo) 1983;31(2):741-744. Google Scholar | Crossref | Medline | ISI | |
| 12. Wang G, Zhang J, Mizuno T, et al. Antitumor active polysaccharides from the Chinese mushroom Songshan Lingzhi, the fruiting body of Ganoderma tsugae. Biosci Biotechnol Biochem. 1993;57(6):894-900. Google Scholar | Crossref | Medline | ISI | |
| 13. Zhang J, Wang G, Li H, et al. Antitumor active protein-containing glycans from the Chinese mushroom Songshan Lingzhi, Ganoderma tsugaemycelium. Biosci Biotechnol Biochem. 1994;58(7):1202-1205. Google Scholar | Crossref | Medline | ISI | |
| 14. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002;60(3),258-274. Google Scholar | Crossref | Medline | ISI | |
| 15. Wang SY, Hsu ML, Hsu HC, Lee SS, Shiao MS, Ho CK. The antitumor effect of Ganoderma lucidumis mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer. 1997;70(6):699-705. Google Scholar | Crossref | Medline | ISI | |
| 16. Hsu MJ, Lee SS, Lin WW. Polysaccharide purified from Ganoderma luciduminhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phospatidylinositol 3 kinase/Akt pathways. J Leuokoc Biol. 2002;72(1):207-216. Google Scholar | |
| 17. Hsu MJ, Lee SS, Lee ST, Lin WW. Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum. Brit J Pharmacol. 2003;139(2):289-298. Google Scholar | Crossref | Medline | ISI | |
| 18. Kim HS, Kacew S, Lee BM. In vitro chemopreventive effects of plant polysaccharides (Aloe barbadendis Miller, Lentis edodes, Ganoderma lucidumand Coriolus versicolor). Carcinogenesis. 1999;20(8):1637-1640. Google Scholar | Crossref | Medline | ISI | |
| 19. Pincemail JJ. Free radicals and antioxidants in human diseases. In: Favier AE, Cadet J, Kalyanaraman B, Fontecave M, Pierre JL, eds. Analysis ofFr ee Radicals in Biological Systems. Berlin, Germany: Birkhauser Verlag; 1995:83-98. Google Scholar | |
| 20. Lee JM, Kwon H, Jeong H, et al. Inhibition of lipid peroxidation and oxidative damage by Ganoderma lucidum. Phytother Res. 2001;15(3):245-249. Google Scholar | Crossref | Medline | ISI | |
| 21. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum(Reishi) polysaccharides: functional and proteomic analysis of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem. 2002;10(4):1057-1062. Google Scholar | Crossref | Medline | ISI | |
| 22. Zhang J, Tang Q, Zimmerman-Kordman M, Reutter W, Fan H. Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum. Life Sci. 2002;71(6):623-638. Google Scholar | Crossref | Medline | ISI | |
| 23. Mizushina Y, Hanashima L, Yamaguchi T, et al. A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases. Biochem Biophys Res Commun. 1998; 249(1):12-22. Google Scholar | |
| 24. Shiao MS, Lee KR, Lin LJ, Wang CT. Natural products and biological activities of the Chinese medical fungus, Ganoderma lucidum. In: Ho CT, Osawa T, Huang MT, Rosen RT, eds. Food Phytochemicals for Cancer Prevention. II: Teas, Spices, and Herbs. Washington, DC: American Chemical Society; 1994: 342-354. Google Scholar | |
| 25. Toth JO, Luu B, Ourission G. Les acides ganoderiques T & Z: triterpenes cytotoxiques de Ganodermalucidum (Polyporacee). Tetrahedron Lett. 1983;24(10):1081-1084. Google Scholar | |
| 26. Lee S, Park S, Oh JW, Yang C. Natural inhibitors for protein prenyltransferase. Planta Medica. 1998;64(4):303-308. Google Scholar | Crossref | Medline | ISI | |
| 27. Min BS, Nakamura N, Miyashiro H,Bae KW, Hattori M. Triterpenes from the spores of Ganoderma lucidumand their activity against HIV-1protease. Chem Pharm Bull. 1998; 46(10):1607-1612. Google Scholar | Crossref | Medline | ISI | |
| 28. El-Mekkawy S, Meselhy MR, Nakamura N, et al. Anti-HIV-1and antiHIV-1-protease substances from Ganoderma lucidum. Phytochemistry. 1998;49(6):1651-1657. Google Scholar | Crossref | Medline | ISI | |
| 29. Min BS, Gao JJ, Nakamura N, Hattori M. Triterpenes from the spores of Ganoderma lucidumand their cytotoxicity against Meth-A and LLC tumor cells. Chem Pharm Bull. 2000; 48(7):1026-1033. Google Scholar | Crossref | Medline | ISI | |
| 30. Kimura Y, Taniguchi M, Baba K. Antitumor and antimetastic effects on liver triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res. 2002;22(6A):3309-3318. Google Scholar | Medline | ISI | |
| 31. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002;50(21):6072-6077. Google Scholar | Crossref | Medline | ISI | |
| 32. Liu X, Yuan JP, Chung CK, Chen XJ. Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum. Cancer Lett. 2002;182(2):155-161. Google Scholar | Crossref | Medline | ISI | |
| 33. Wilasrusmee C, Kittur S, Siddiqui J, Bruch D, Wilasrusmee S, Kittur DS. In vitro immunomodulatory effects of ten commonly used herbs on murine lymphocytes. J Altern Complement Med. 2002;8(4):467-475. Google Scholar | Crossref | Medline | ISI | |
| 34. Sliva D, English D, Lyons D, Lloyd FP Jr. Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator (uPA) through the activation of AP-1and NF- .B. Biochem Biophys Res Commun. 2002; 290(1):552-557. Google Scholar | Crossref | Medline | ISI | |
| 35. Sliva D, Rizzo MT, English D. Phosphatidylinositol 3-kinase and NF- .B regulate motility of invasive MDA-MB-231human breast cancer cells by the secretion of urokinase-type plasminogen activator. J Biol Chem. 2002;277(5):3150-3157. Google Scholar | Crossref | Medline | ISI | |
| 36. Sliva D, Labarrere C, Slivova V, Sedlak M, Lloyd FP Jr, Ho NWY. Ganoderma lucidumsuppresses motility of highly invasive breast and prostate cancer cells. Biochem Biophys Res Commun. 2002;298(4):603-612b. Google Scholar | Crossref | Medline | ISI | |
| 37. Hu H, Ahn NS, Yang X, Lee YS, Kang KS. Ganoderma lucidumextract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer. 2002;102(3):250-253. Google Scholar | Crossref | Medline | ISI | |
| 38. Lin SB, Li CH, Lee SS, Kan LS. Triterpene-enriched extracts from Ganoderma luciduminhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci. 2003; 72(2):2381-2390. Google Scholar | Crossref | Medline | ISI | |
| 39. Cheung WMW, Hui WS, Chu PWK, Chiu SW, Ip NW. Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett. 2000;486(3):291-296. Google Scholar | Crossref | Medline | ISI | |
| 40. Sliva D, Sedlak M, Slivova V, Valachovicova T, Lloyd FP Jr., Ho NWY. Biologic activity of Ganoderma lucidumfor the inhibition of highly invasive breast and prostate cancer cells. J Altern Complement Med. 2003;9(4):491-497. Google Scholar | Crossref | Medline | ISI | |
| 41. Hattori M. Recent studies on the bitter principles of Ganoderma lucidum—isolation of novel triterpenes, their biological activity and pharmacokinetics. Proceedings of the Int. Symposium Ganoderma Sci.; April 27-29, 2001; Auckland, New Zealand. Google Scholar | |
| 42. http://www.cfsan.fda.gov. Google Scholar | |
| 43. Wang CY, Cusack JC Jr, Liu R, Baldwin AS Jr. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nature Med. 1999;5(4):412-417. Google Scholar | Crossref | Medline | ISI | |
| 44. Ludes-Meyers JH, Liu Y, Munoz-Medellin D, Hilsenbeck SG, Brown PH. AP-1blockade inhibits the growth of normal and malignant breast cells. Oncogene. 2001;20(22):2771-2780. Google Scholar | Crossref | Medline | ISI | |
| 45. Lengyel E, Gum R, Stepp E, Juarez J, Wang H, Boyd D. Regulation of urokinase-type plasminogen activator expression by an ERK1-dependent signaling pathway in a squamous cell carcinoma cell line. J Cell Biochem. 1996;61(3):430-443. Google Scholar | Crossref | Medline | ISI | |
| 46. Wang Y. The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis. Med Res Rev. 2001;21(2):146-170. Google Scholar | Crossref | Medline | ISI | |
| 47. Schorr K, Li M, Krajewski S, Reed JC, Furth PA. Bcl-2 gene family and related proteins in mammary gland involution and breast cancer. J Mam Gland Biol. Neoplasia. 1999;4(2):153-164. Google Scholar | Crossref | Medline | ISI | |
| 48. Biswas DK, Cruz AP, Gansberger E, Pardee AB. Epidermal growth factor-induced nuclear factor .B activation: a major pathway of cell cycle progression in estrogen-receptor negative breast cancer cells. Proc Natl Acad Sci USA. 2000;97(15):8542-8547. Google Scholar | Crossref | Medline | ISI | |
| 49. van Moorselaar RJA, Voest EE. Angiogenesis in prostate cancer: its role in disease progression and possible therapeutic approaches. Mol Cell Endocrinol. 2002;197(1-2):239-250. Google Scholar | Crossref | Medline | ISI |
